HPV infection and intraepithelial lesions: Comparison between HIV-positive and negative women

Research output: Contribution to journalArticle

Abstract

Introduction: Human Papillomavirus infections have been shown to be crucial for the development of cervical intraepithelial neoplasia and subsequent cervical cancer. The aim of this study is to describe the prevalence of different genotypes of HPV, in a population of HIV-positive women, compared to the negative ones, and their oncogenic risk. Patients and Method: A case-control study comparing HPV genotype distribution between 93 HIV-seropositive and 186 HIV-seronegative women, matched for age and severity of cervical lesions, who attending colposcopic service of our departments for periodical Pap smear and HPV DNA full genotyping by SPF-10 LiPA assay. Results: No significant difference was found in genotype distribution between HIV positive and HIV negative women. Only the prevalence of HPV56 was higher in HIV positive women (p=0,046). The rates of HPV 6, 11, 16 and 18 were similar in both groups. The likelihood of the detection of three or more HPV genotypes was significantly associated with CIN (OR=2.0; 95% CI=1.1-3.8; p= 0.026) but only marginally to HIV-positive serostatus (OR=1.68; 95% CI=0.89-3.16; p= 0.1). High grade cervical lesions are associated with high risk viruses like HPV 16 and 18 and with multiple cervical HPV infections. Conclusions: The tendency to treat HIV disease with high active antiretroviral therapy may reduce the impact of immunosuppression and make the course of such HPV infections more similar to that among women who are not HIVinfected. As in immunocompetent women, high oncogenic risk viral type and multiple infections are associated with a histologically proven cervical intraepithelial lesions.

Original languageEnglish
Pages (from-to)614-619
Number of pages6
JournalCurrent HIV Research
Volume10
Issue number7
Publication statusPublished - 2012

Fingerprint

HIV
Infection
Genotype
Human papillomavirus 18
Human papillomavirus 11
Human papillomavirus 6
Papanicolaou Test
Cervical Intraepithelial Neoplasia
Papillomavirus Infections
Human papillomavirus 16
Virus Diseases
Uterine Cervical Neoplasms
Immunosuppression
Case-Control Studies
Viruses
DNA
Population

Keywords

  • Antiretroviral therapy
  • Cevical intraepithelial neoplasia
  • HIV
  • HPV genotypes
  • Immunosuppression
  • Oncogenic risk

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

HPV infection and intraepithelial lesions : Comparison between HIV-positive and negative women. / Roccio, M.; Dal Bello, B.; Gardella, B.; Carrara, M.; Gulminetti, R.; Mariani, B.; Spinillo, A.

In: Current HIV Research, Vol. 10, No. 7, 2012, p. 614-619.

Research output: Contribution to journalArticle

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abstract = "Introduction: Human Papillomavirus infections have been shown to be crucial for the development of cervical intraepithelial neoplasia and subsequent cervical cancer. The aim of this study is to describe the prevalence of different genotypes of HPV, in a population of HIV-positive women, compared to the negative ones, and their oncogenic risk. Patients and Method: A case-control study comparing HPV genotype distribution between 93 HIV-seropositive and 186 HIV-seronegative women, matched for age and severity of cervical lesions, who attending colposcopic service of our departments for periodical Pap smear and HPV DNA full genotyping by SPF-10 LiPA assay. Results: No significant difference was found in genotype distribution between HIV positive and HIV negative women. Only the prevalence of HPV56 was higher in HIV positive women (p=0,046). The rates of HPV 6, 11, 16 and 18 were similar in both groups. The likelihood of the detection of three or more HPV genotypes was significantly associated with CIN (OR=2.0; 95{\%} CI=1.1-3.8; p= 0.026) but only marginally to HIV-positive serostatus (OR=1.68; 95{\%} CI=0.89-3.16; p= 0.1). High grade cervical lesions are associated with high risk viruses like HPV 16 and 18 and with multiple cervical HPV infections. Conclusions: The tendency to treat HIV disease with high active antiretroviral therapy may reduce the impact of immunosuppression and make the course of such HPV infections more similar to that among women who are not HIVinfected. As in immunocompetent women, high oncogenic risk viral type and multiple infections are associated with a histologically proven cervical intraepithelial lesions.",
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T2 - Comparison between HIV-positive and negative women

AU - Roccio, M.

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AU - Gardella, B.

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AU - Gulminetti, R.

AU - Mariani, B.

AU - Spinillo, A.

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N2 - Introduction: Human Papillomavirus infections have been shown to be crucial for the development of cervical intraepithelial neoplasia and subsequent cervical cancer. The aim of this study is to describe the prevalence of different genotypes of HPV, in a population of HIV-positive women, compared to the negative ones, and their oncogenic risk. Patients and Method: A case-control study comparing HPV genotype distribution between 93 HIV-seropositive and 186 HIV-seronegative women, matched for age and severity of cervical lesions, who attending colposcopic service of our departments for periodical Pap smear and HPV DNA full genotyping by SPF-10 LiPA assay. Results: No significant difference was found in genotype distribution between HIV positive and HIV negative women. Only the prevalence of HPV56 was higher in HIV positive women (p=0,046). The rates of HPV 6, 11, 16 and 18 were similar in both groups. The likelihood of the detection of three or more HPV genotypes was significantly associated with CIN (OR=2.0; 95% CI=1.1-3.8; p= 0.026) but only marginally to HIV-positive serostatus (OR=1.68; 95% CI=0.89-3.16; p= 0.1). High grade cervical lesions are associated with high risk viruses like HPV 16 and 18 and with multiple cervical HPV infections. Conclusions: The tendency to treat HIV disease with high active antiretroviral therapy may reduce the impact of immunosuppression and make the course of such HPV infections more similar to that among women who are not HIVinfected. As in immunocompetent women, high oncogenic risk viral type and multiple infections are associated with a histologically proven cervical intraepithelial lesions.

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