HPV infection in the oral cavity: Epidemiology, clinical manifestations and relationship with oral cancer

V. Candotto, D. Lauritano, M. Nardone, L. Baggi, C. Arcuri, R. Gatto, R. M. Gaudio, F. Spadari, Francesco Carinci

Research output: Contribution to journalReview articlepeer-review


Purpose. The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions. Materials and methods. A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Therapeutic protocols are also described where necessary. Results. In recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. Even if the mass media have increasingly faced the problem, causing frequent alarming among patients, the dentist therefore needs a complete and up-to-date knowledge of this infectious condition that is one of the most common causes of sexually transmitted mucous membrane infections (e.g. genital, anal and oral). Conclusions. Recent studies about HPV infection are a basic requirement in order to promote the health of patients and provide them with the most exhaustive indications from dentists.

Original languageEnglish
Pages (from-to)209-220
Number of pages12
JournalORAL and Implantology
Issue number3
Publication statusPublished - Jul 1 2017
Externally publishedYes


  • Anti-HPV vaccines
  • HPV test
  • Human papillomavirus
  • Oral infections
  • Oropharynx carcinoma
  • Sexual transmission

ASJC Scopus subject areas

  • Dentistry(all)


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