HPV-Testing in follow-up of patients treated for CIN2+ lesions

Luciano Mariani, Maria Teresa Sandri, Mario Preti, Massimo Origoni, Silvano Costa, P. Cristoforoni, Fabio Bottari, Mario Giovanni Sideri

Research output: Contribution to journalArticlepeer-review


Persistent positivity of HPV-DNA testing is considered a prognostic index of recurrent disease in patients treated for CIN2+. HPV detection, and particularly genotyping, has an adequate high rate of sensitivity and specificity (along with an optimal reproducibility), for accurately predicting treatment failure, allowing for an intensified monitoring activity. Conversely, women with a neg-ative HPV-test 6 months after therapy have a very low risk for residual/recurrent disease, which leads to a more individualized follow-up schedule, allowing for a gradual return to the normal screening scheme. HPV testing should be routinely included (with or without cytology) in post-treatment follow-up of CIN2+ patients for early detection of recurrence and cancer pro-gression. HPV genotyping methods, as a biological indicator of persistent disease, could be more suitable for a predictive role and risk stratification (particularly in the case of HPV 16/18 persis-tence) than pooled HPV-based testing. However, it is necessary to be aware of the performance of the system, adhering to strict standardization of the process and quality assurance criteria.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of Cancer
Issue number1
Publication statusPublished - 2016


  • CIN recurrence
  • CIN2+
  • Follow-up
  • Genotyping
  • HPV-testing

ASJC Scopus subject areas

  • Oncology


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