HPV type distribution in invasive cervical cancers in Italy: Pooled analysis of three large studies

Paolo Giorgi Rossi, Mario Sideri, Francesca Maria Carozzi, Amina Vocaturo, Franco Maria Buonaguro, Maria Lina Tornesello, Elena Burroni, Luciano Mariani, Sara Boveri, Leandra Maria Zaffina, Francesco Chini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study is to describe the prevalence of HPV types in invasive cervical cancers in Italy from 1996 to 2008. Methods: A pooled analysis of the three largest case series typed to date was performed. HPV typing was performed on paraffin-embedded slices. Molecular analyses were performed in four laboratories. Multivariate analyses were performed to test the associations between calendar time, age, and geographical area and the proportion of types 16/18. Results: Out of 574 cancers, 24 (4.2%) were HPV negative. HPV 16 and 18 were responsible for 74.4% (378/508) and 80.3% (49/61) of the squamous cancers and adenocarcinomas, respectively. Other frequent types were 31 (9.5%), 45 (6.4%), and 58 (3.3%) for squamous cancers and 45 (13.3%), 31, 35, and 58 (5.0%) for adenocarcinomas. The proportion of HPV 16 and/or 18 decreased with age (p-value for trend

Original languageEnglish
Pages (from-to)26
Number of pages1
JournalInfectious Agents and Cancer
DOIs
Publication statusAccepted/In press - Oct 12 2012

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Infectious Diseases

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