HRAS1 proto-oncogene polymorphisms in human malignant melanoma: TaqI defined alleles significantly associated with the disease

P. Radice; M. A. Pierotti; M. G. Borrello; M. T. Illeni; D. Rovini; G. D. Porta

HRAS1 proto-oncogene polymorphisms in human malignant melanoma: TaqI defined alleles significantly associated with the disease

P. Radice, M. A. Pierotti, M. G. Borrello, M. T. Illeni, D. Rovini, G. D. Porta

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

We have analysed the DNA of peripheral blood leukocytes (PBL) from 55 melanoma patients and 53 healthy individuals and failed to find any significant association between melanoma and rare HRAS1 alleles defined by MspI/HpaII digestion. However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Oncogene
Volume	2
Issue number	1
Publication status	Published - 1987

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "We have analysed the DNA of peripheral blood leukocytes (PBL) from 55 melanoma patients and 53 healthy individuals and failed to find any significant association between melanoma and rare HRAS1 alleles defined by MspI/HpaII digestion. However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors.",

author = "P. Radice and Pierotti, {M. A.} and Borrello, {M. G.} and Illeni, {M. T.} and D. Rovini and Porta, {G. D.}",

year = "1987",

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volume = "2",

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journal = "Oncogene",

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T1 - HRAS1 proto-oncogene polymorphisms in human malignant melanoma

T2 - TaqI defined alleles significantly associated with the disease

AU - Radice, P.

AU - Pierotti, M. A.

AU - Borrello, M. G.

AU - Illeni, M. T.

AU - Rovini, D.

AU - Porta, G. D.

PY - 1987

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AB - We have analysed the DNA of peripheral blood leukocytes (PBL) from 55 melanoma patients and 53 healthy individuals and failed to find any significant association between melanoma and rare HRAS1 alleles defined by MspI/HpaII digestion. However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors.

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