Abstract
Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use. We assessed the risk of breast cancer associated with HRT use in 54,548 postmenopausal women who had never taken any HRT one year before entering the E3N-EPIC cohort study (mean age at inclusion: 52.8 years). 948 primary invasive breast cancers were diagnosed during follow-up (mean duration: 5.8 years). Data were analysed using multivariate Cox proportional hazards models. In this cohort where the mean duration of HRT use was 2.8 years, an increased risk in HRT users compared with non-users was found (relative risk (RR) 1.2 [95% confidence interval 1.1-1.4]). The RR was 1.1 [0.8-1.6] for estrogens used alone and 1.3 [1.1-1.5] when used in combination with oral progestogens. The risk was significantly greater (p
| Original language | French |
|---|---|
| Pages (from-to) | 186-193 |
| Number of pages | 8 |
| Journal | Reproduction Humaine et Hormones |
| Volume | 18 |
| Issue number | 5 |
| Publication status | Published - Jun 2005 |
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Keywords
- Breast cancer
- Cohort study
- Hormone Replacement Therapy
- Menopause
- Risk factor
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
THS et risque de cancer du sein - Résultats de la cohorte E3N. / Fournier, Agnès; Berrino, Franco; Riboli, Elio; Avenel, Valérie; Clavel-Chapelon, Françoise.
In: Reproduction Humaine et Hormones, Vol. 18, No. 5, 06.2005, p. 186-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - THS et risque de cancer du sein - Résultats de la cohorte E3N
AU - Fournier, Agnès
AU - Berrino, Franco
AU - Riboli, Elio
AU - Avenel, Valérie
AU - Clavel-Chapelon, Françoise
PY - 2005/6
Y1 - 2005/6
N2 - Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use. We assessed the risk of breast cancer associated with HRT use in 54,548 postmenopausal women who had never taken any HRT one year before entering the E3N-EPIC cohort study (mean age at inclusion: 52.8 years). 948 primary invasive breast cancers were diagnosed during follow-up (mean duration: 5.8 years). Data were analysed using multivariate Cox proportional hazards models. In this cohort where the mean duration of HRT use was 2.8 years, an increased risk in HRT users compared with non-users was found (relative risk (RR) 1.2 [95% confidence interval 1.1-1.4]). The RR was 1.1 [0.8-1.6] for estrogens used alone and 1.3 [1.1-1.5] when used in combination with oral progestogens. The risk was significantly greater (p
AB - Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use. We assessed the risk of breast cancer associated with HRT use in 54,548 postmenopausal women who had never taken any HRT one year before entering the E3N-EPIC cohort study (mean age at inclusion: 52.8 years). 948 primary invasive breast cancers were diagnosed during follow-up (mean duration: 5.8 years). Data were analysed using multivariate Cox proportional hazards models. In this cohort where the mean duration of HRT use was 2.8 years, an increased risk in HRT users compared with non-users was found (relative risk (RR) 1.2 [95% confidence interval 1.1-1.4]). The RR was 1.1 [0.8-1.6] for estrogens used alone and 1.3 [1.1-1.5] when used in combination with oral progestogens. The risk was significantly greater (p
KW - Breast cancer
KW - Cohort study
KW - Hormone Replacement Therapy
KW - Menopause
KW - Risk factor
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UR - http://www.scopus.com/inward/citedby.url?scp=23644458144&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:23644458144
VL - 18
SP - 186
EP - 193
JO - Reproduction Humaine et Hormones
JF - Reproduction Humaine et Hormones
SN - 0994-3919
IS - 5
ER -