Abstract
Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use. We assessed the risk of breast cancer associated with HRT use in 54,548 postmenopausal women who had never taken any HRT one year before entering the E3N-EPIC cohort study (mean age at inclusion: 52.8 years). 948 primary invasive breast cancers were diagnosed during follow-up (mean duration: 5.8 years). Data were analysed using multivariate Cox proportional hazards models. In this cohort where the mean duration of HRT use was 2.8 years, an increased risk in HRT users compared with non-users was found (relative risk (RR) 1.2 [95% confidence interval 1.1-1.4]). The RR was 1.1 [0.8-1.6] for estrogens used alone and 1.3 [1.1-1.5] when used in combination with oral progestogens. The risk was significantly greater (p
Translated title of the contribution | HRT and breast cancer risk - Results of the E3N-EPIC cohort |
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Original language | French |
Pages (from-to) | 186-193 |
Number of pages | 8 |
Journal | Reproduction Humaine et Hormones |
Volume | 18 |
Issue number | 5 |
Publication status | Published - Jun 2005 |
Keywords
- Breast cancer
- Cohort study
- Hormone Replacement Therapy
- Menopause
- Risk factor
ASJC Scopus subject areas
- Obstetrics and Gynaecology