THS et risque de cancer du sein - Résultats de la cohorte E3N

Translated title of the contribution: HRT and breast cancer risk - Results of the E3N-EPIC cohort

Agnès Fournier, Franco Berrino, Elio Riboli, Valérie Avenel, Françoise Clavel-Chapelon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use. We assessed the risk of breast cancer associated with HRT use in 54,548 postmenopausal women who had never taken any HRT one year before entering the E3N-EPIC cohort study (mean age at inclusion: 52.8 years). 948 primary invasive breast cancers were diagnosed during follow-up (mean duration: 5.8 years). Data were analysed using multivariate Cox proportional hazards models. In this cohort where the mean duration of HRT use was 2.8 years, an increased risk in HRT users compared with non-users was found (relative risk (RR) 1.2 [95% confidence interval 1.1-1.4]). The RR was 1.1 [0.8-1.6] for estrogens used alone and 1.3 [1.1-1.5] when used in combination with oral progestogens. The risk was significantly greater (p

Original languageFrench
Pages (from-to)186-193
Number of pages8
JournalReproduction Humaine et Hormones
Volume18
Issue number5
Publication statusPublished - Jun 2005

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Hormone Replacement Therapy
Breast Neoplasms
Progestins
Proportional Hazards Models
Epidemiologic Studies
Estrogens
Cohort Studies
Confidence Intervals

Keywords

  • Breast cancer
  • Cohort study
  • Hormone Replacement Therapy
  • Menopause
  • Risk factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Fournier, A., Berrino, F., Riboli, E., Avenel, V., & Clavel-Chapelon, F. (2005). THS et risque de cancer du sein - Résultats de la cohorte E3N. Reproduction Humaine et Hormones, 18(5), 186-193.

THS et risque de cancer du sein - Résultats de la cohorte E3N. / Fournier, Agnès; Berrino, Franco; Riboli, Elio; Avenel, Valérie; Clavel-Chapelon, Françoise.

In: Reproduction Humaine et Hormones, Vol. 18, No. 5, 06.2005, p. 186-193.

Research output: Contribution to journalArticle

Fournier, A, Berrino, F, Riboli, E, Avenel, V & Clavel-Chapelon, F 2005, 'THS et risque de cancer du sein - Résultats de la cohorte E3N', Reproduction Humaine et Hormones, vol. 18, no. 5, pp. 186-193.
Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F. THS et risque de cancer du sein - Résultats de la cohorte E3N. Reproduction Humaine et Hormones. 2005 Jun;18(5):186-193.
Fournier, Agnès ; Berrino, Franco ; Riboli, Elio ; Avenel, Valérie ; Clavel-Chapelon, Françoise. / THS et risque de cancer du sein - Résultats de la cohorte E3N. In: Reproduction Humaine et Hormones. 2005 ; Vol. 18, No. 5. pp. 186-193.
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