Abstract
Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV. From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated. HS1,2 allele ·1 has been associated with nonprogressors (allelic frequency: 51.19% versus 33.87% in progressors, OR 0.5, and P=0.0437), while allele ·2 has been associated with progression (allelic frequency: 48.39% versus 30.95% in nonprogressors, OR 2.1, and P=0.0393). Further, only subjects carrying allele ·2 in absence of allele ·1, either in homozygous condition for allele ·2 [nonprogressors 2/42 (4.76%), Progressors 7/31 (22.58%), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67%), Progressors 13/31 (41.93%), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS. In conclusion, while the HS1,2 allele ·1 has a protective effect on HIV progression when present, allele ·2 is associated with progression toward AIDS when allele ·1 is absent.
| Original language | English |
|---|---|
| Article number | 637523 |
| Journal | BioMed Research International |
| Volume | 2014 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain. / Montesano, Carla; Giambra, Vincenzo; Frezza, Domenico; Palma, Paolo; Serone, Eliseo; Gattinara, Guido Castelli; Mattei, Maurizio; Mancino, Giorgio; Colizzi, Vittorio; Amicosante, Massimo.
In: BioMed Research International, Vol. 2014, 637523, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain
AU - Montesano, Carla
AU - Giambra, Vincenzo
AU - Frezza, Domenico
AU - Palma, Paolo
AU - Serone, Eliseo
AU - Gattinara, Guido Castelli
AU - Mattei, Maurizio
AU - Mancino, Giorgio
AU - Colizzi, Vittorio
AU - Amicosante, Massimo
PY - 2014
Y1 - 2014
N2 - Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV. From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated. HS1,2 allele ·1 has been associated with nonprogressors (allelic frequency: 51.19% versus 33.87% in progressors, OR 0.5, and P=0.0437), while allele ·2 has been associated with progression (allelic frequency: 48.39% versus 30.95% in nonprogressors, OR 2.1, and P=0.0393). Further, only subjects carrying allele ·2 in absence of allele ·1, either in homozygous condition for allele ·2 [nonprogressors 2/42 (4.76%), Progressors 7/31 (22.58%), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67%), Progressors 13/31 (41.93%), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS. In conclusion, while the HS1,2 allele ·1 has a protective effect on HIV progression when present, allele ·2 is associated with progression toward AIDS when allele ·1 is absent.
AB - Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV. From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated. HS1,2 allele ·1 has been associated with nonprogressors (allelic frequency: 51.19% versus 33.87% in progressors, OR 0.5, and P=0.0437), while allele ·2 has been associated with progression (allelic frequency: 48.39% versus 30.95% in nonprogressors, OR 2.1, and P=0.0393). Further, only subjects carrying allele ·2 in absence of allele ·1, either in homozygous condition for allele ·2 [nonprogressors 2/42 (4.76%), Progressors 7/31 (22.58%), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67%), Progressors 13/31 (41.93%), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS. In conclusion, while the HS1,2 allele ·1 has a protective effect on HIV progression when present, allele ·2 is associated with progression toward AIDS when allele ·1 is absent.
UR - http://www.scopus.com/inward/record.url?scp=84902262949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902262949&partnerID=8YFLogxK
U2 - 10.1155/2014/637523
DO - 10.1155/2014/637523
M3 - Article
C2 - 25009819
AN - SCOPUS:84902262949
VL - 2014
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 637523
ER -