HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain

Carla Montesano, Vincenzo Giambra, Domenico Frezza, Paolo Palma, Eliseo Serone, Guido Castelli Gattinara, Maurizio Mattei, Giorgio Mancino, Vittorio Colizzi, Massimo Amicosante

Research output: Contribution to journalArticle

Abstract

Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV. From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated. HS1,2 allele ·1 has been associated with nonprogressors (allelic frequency: 51.19% versus 33.87% in progressors, OR 0.5, and P=0.0437), while allele ·2 has been associated with progression (allelic frequency: 48.39% versus 30.95% in nonprogressors, OR 2.1, and P=0.0393). Further, only subjects carrying allele ·2 in absence of allele ·1, either in homozygous condition for allele ·2 [nonprogressors 2/42 (4.76%), Progressors 7/31 (22.58%), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67%), Progressors 13/31 (41.93%), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS. In conclusion, while the HS1,2 allele ·1 has a protective effect on HIV progression when present, allele ·2 is associated with progression toward AIDS when allele ·1 is absent.

Original languageEnglish
Article number637523
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Immunoglobulin Heavy Chains
Pediatrics
Nucleic Acid Regulatory Sequences
Polymorphism
Acquired Immunodeficiency Syndrome
Alleles
HIV
Disease Outbreaks
Humoral Immunity
HIV Infections

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain. / Montesano, Carla; Giambra, Vincenzo; Frezza, Domenico; Palma, Paolo; Serone, Eliseo; Gattinara, Guido Castelli; Mattei, Maurizio; Mancino, Giorgio; Colizzi, Vittorio; Amicosante, Massimo.

In: BioMed Research International, Vol. 2014, 637523, 2014.

Research output: Contribution to journalArticle

Montesano, C, Giambra, V, Frezza, D, Palma, P, Serone, E, Gattinara, GC, Mattei, M, Mancino, G, Colizzi, V & Amicosante, M 2014, 'HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain', BioMed Research International, vol. 2014, 637523. https://doi.org/10.1155/2014/637523
Montesano, Carla ; Giambra, Vincenzo ; Frezza, Domenico ; Palma, Paolo ; Serone, Eliseo ; Gattinara, Guido Castelli ; Mattei, Maurizio ; Mancino, Giorgio ; Colizzi, Vittorio ; Amicosante, Massimo. / HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain. In: BioMed Research International. 2014 ; Vol. 2014.
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abstract = "Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3′ regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a cohort of HIV infected pediatric subjects from a nosocomial outbreak with a monophyletic strain of HIV. From a total group of 418 HIV infected children in the outbreak cohort, 42 nonprogressors and 31 progressors without bias due to antiretroviral therapy were evaluated. HS1,2 allele ·1 has been associated with nonprogressors (allelic frequency: 51.19{\%} versus 33.87{\%} in progressors, OR 0.5, and P=0.0437), while allele ·2 has been associated with progression (allelic frequency: 48.39{\%} versus 30.95{\%} in nonprogressors, OR 2.1, and P=0.0393). Further, only subjects carrying allele ·2 in absence of allele ·1, either in homozygous condition for allele ·2 [nonprogressors 2/42 (4.76{\%}), Progressors 7/31 (22.58{\%}), OR 5.8, and P=0.0315] or in combination with other allelic variants [nonprogressors 7/42 (16.67{\%}), Progressors 13/31 (41.93{\%}), OR 3.61, and P=0.0321], have been associated with HIV progression to AIDS. In conclusion, while the HS1,2 allele ·1 has a protective effect on HIV progression when present, allele ·2 is associated with progression toward AIDS when allele ·1 is absent.",
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T1 - HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain

AU - Montesano, Carla

AU - Giambra, Vincenzo

AU - Frezza, Domenico

AU - Palma, Paolo

AU - Serone, Eliseo

AU - Gattinara, Guido Castelli

AU - Mattei, Maurizio

AU - Mancino, Giorgio

AU - Colizzi, Vittorio

AU - Amicosante, Massimo

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