HSP-70, C-myc and HLA-DR expression in patients with cutaneous malignant melanoma metastatic in lymph nodes

Alexandra Kalogeraki, F. Garbagnati, K. Darivianaki, G. S. Delides, M. Santinami, E. N. Stathopoulos, O. Zoras

Research output: Contribution to journalArticlepeer-review


HSP-70, C-myc and HLA-DR were examined in patients with cutaneous malignant melanoma metastatic to lymph nodes. Lymph-nodal fine-needle aspiration biopsies (FNABs) were analyzed and the results were correlated to other variables, such as the gender of the patients, Clark level and Breslow thickness of the primary tumor. Thirty cases of metastatic melanoma in lymph nodes from 30 patients with cutaneous malignant melanoma were studied. All patients (100%) had microscopic regional nodal metastasis and a recurrence of the lesion during the first two years. The HSP-70, C-myc and HLA-DR expressions were investigated immunocytologically, using the APAAP (alkaline phosphatase) method on the FNAB samples. The immunocytochemical expressions of HSP-70 protein, C-myc oncogene, and HLA-DR antigen were found in 18 cases (60%), in 14 cases (43.3%) and in 12 cases (40%), respectively. Clark levels were significantly associated with HSP-70 protein (1.5 mm). The clinical course of malignant cutaneous melanoma is related to the expression of these indices, which seem to play a significant role in the metastasis and prognosis of this aggressive tumor. The immunocytochemical expression of HSP-70 in the malignant melanoma tumor could be of particular value in the identification of patients with poor prognosis.

Original languageEnglish
Pages (from-to)3551-3554
Number of pages4
JournalAnticancer Research
Issue number5 A
Publication statusPublished - Sep 2006


  • C-myc oncogene
  • FNAB
  • HLA-DR antigen
  • HSP-70 protein
  • Metastatic malignant melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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