Hsp60 and Hsp10 as antitumor molecular agents

Francesco Cappello, Anna M. Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo, Alberto J L Macario

Research output: Contribution to journalArticle

Abstract

The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.

Original languageEnglish
Pages (from-to)487-489
Number of pages3
JournalCancer Biology and Therapy
Volume6
Issue number4
Publication statusPublished - Apr 2007

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Keywords

  • Cancer
  • Cpn10
  • Hsp60
  • Immunostimulation
  • Immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cappello, F., Czarnecka, A. M., La Rocca, G., Di Stefano, A., Zummo, G., & Macario, A. J. L. (2007). Hsp60 and Hsp10 as antitumor molecular agents. Cancer Biology and Therapy, 6(4), 487-489.