HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma

Milena Urbini, Annalisa Astolfi, Maria Abbondanza Pantaleo, Salvatore Serravalle, Angelo Paolo Dei Tos, Piero Picci, Valentina Indio, Marta Sbaraglia, Stefania Benini, Alberto Righi, Marco Gambarotti, Alessandro Gronchi, Chiara Colombo, Gian Paolo Dagrada, Silvana Pilotti, Roberta Maestro, Maurizio Polano, Maristella Saponara, Giuseppe Tarantino, Andrea PessionGuido Biasco, Paolo Giovanni Casali, Silvia Stacchiotti

Research output: Contribution to journalArticle

Abstract

Extraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of the bone have been reported. EMC exhibits distinctive clinico-pathological and genetic features; however, despite the name, it lacks any feature of cartilaginous differentiation. EMC is characterized by the rearrangement of the NR4A3, which, in most cases (about 62-75%), is fused with EWSR1 and less frequently with other partners, including TAF15 (27%), TCF12 (4%), TFG, and FUS. We herein report the identification by whole-transcriptome sequencing of HSPA8 as a novel fusion partner of NR4A3 in a case of EMC. FISH analysis confirmed the presence of a genomic HSPA8-NR4A3 translocation in the vast majority of tumor cells. Our findings expand the spectrum of NR4A3 fusion partners involved in EMC pathobiology.

Original languageEnglish
Pages (from-to)582-586
Number of pages5
JournalGenes Chromosomes and Cancer
Volume56
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Transcriptome
Sarcoma
Names
Extraskeletal Myxoid Chondrosarcoma
Bone and Bones
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Urbini, M., Astolfi, A., Pantaleo, M. A., Serravalle, S., Dei Tos, A. P., Picci, P., ... Stacchiotti, S. (2017). HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes and Cancer, 56(7), 582-586. https://doi.org/10.1002/gcc.22462

HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. / Urbini, Milena; Astolfi, Annalisa; Pantaleo, Maria Abbondanza; Serravalle, Salvatore; Dei Tos, Angelo Paolo; Picci, Piero; Indio, Valentina; Sbaraglia, Marta; Benini, Stefania; Righi, Alberto; Gambarotti, Marco; Gronchi, Alessandro; Colombo, Chiara; Dagrada, Gian Paolo; Pilotti, Silvana; Maestro, Roberta; Polano, Maurizio; Saponara, Maristella; Tarantino, Giuseppe; Pession, Andrea; Biasco, Guido; Casali, Paolo Giovanni; Stacchiotti, Silvia.

In: Genes Chromosomes and Cancer, Vol. 56, No. 7, 01.07.2017, p. 582-586.

Research output: Contribution to journalArticle

Urbini, M, Astolfi, A, Pantaleo, MA, Serravalle, S, Dei Tos, AP, Picci, P, Indio, V, Sbaraglia, M, Benini, S, Righi, A, Gambarotti, M, Gronchi, A, Colombo, C, Dagrada, GP, Pilotti, S, Maestro, R, Polano, M, Saponara, M, Tarantino, G, Pession, A, Biasco, G, Casali, PG & Stacchiotti, S 2017, 'HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma', Genes Chromosomes and Cancer, vol. 56, no. 7, pp. 582-586. https://doi.org/10.1002/gcc.22462
Urbini M, Astolfi A, Pantaleo MA, Serravalle S, Dei Tos AP, Picci P et al. HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes and Cancer. 2017 Jul 1;56(7):582-586. https://doi.org/10.1002/gcc.22462
Urbini, Milena ; Astolfi, Annalisa ; Pantaleo, Maria Abbondanza ; Serravalle, Salvatore ; Dei Tos, Angelo Paolo ; Picci, Piero ; Indio, Valentina ; Sbaraglia, Marta ; Benini, Stefania ; Righi, Alberto ; Gambarotti, Marco ; Gronchi, Alessandro ; Colombo, Chiara ; Dagrada, Gian Paolo ; Pilotti, Silvana ; Maestro, Roberta ; Polano, Maurizio ; Saponara, Maristella ; Tarantino, Giuseppe ; Pession, Andrea ; Biasco, Guido ; Casali, Paolo Giovanni ; Stacchiotti, Silvia. / HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. In: Genes Chromosomes and Cancer. 2017 ; Vol. 56, No. 7. pp. 582-586.
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