HTLV-1 and HTLV-2: Highly similar viruses with distinct oncogenic properties

Vincenzo Ciminale, Francesca Rende, Umberto Bertazzoni, Maria G. Romanelli

Research output: Contribution to journalArticle

Abstract

HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.

Original languageEnglish
JournalFrontiers in Microbiology
Volume5
Issue numberJULY
DOIs
Publication statusPublished - 2014

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Keywords

  • APH2
  • Clonality
  • HBZ
  • HTLV
  • Rex
  • Tax

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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