HTLV-III infection among 315 intravenous drug abusers: Seroepidemiological, clinical, and pathological findings

U. Tirelli, E. Vaccher, A. Carbone, S. Diodato, R. Sorio, R. Bosio, R. Tamburlini, D. Crotti, M. Crovatto, P. De Paoli

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts' assistance in the Friuli Venezia-Ciulia region of Italy, close to the borders of Austria and Yugoslavia. No case of AIDS has been observed. Sixty-five (21%) were affected by persistent generalized lymphadenopathy (PGL). HTLV-III seropositivity was noted in 86 (27%) of the overall 315 IVDA, in 50 (77%) of 65 patients with PGL, and in 1 (0.5%) of 205 blood donors tested as a control group. Patients with PGL had a significantly lower OKT4/OKT8 ratio than the rest of the IVDA population and controls. Systemic symptoms were present in 52% of the patients with PGL, the most frequent symptoms being fatigue and night sweats. In 20 patients with PGL, DR typing revealed a significant increase in DR-5 frequency and a significant decrease of DR-2 frequency. The predominant histological features in the lymph nodes taken from 25 patients consisted of an exuberant follicular hyperplasia, capillary vessel proliferation, and plasmacytosis. Nineteen (22%) females reporting occasional prostitution were compared to 10 non-IVDA female prostitutes and concomitantly evaluated. HTLV-III seropositivity was noted in 11 (58%) of 19 IVDA female prostitutes and in none of the 10 non-IVDA prostitutes. Thirty-five couples composed of both IVDA were compared to 24 couples composed of an IVDA and a non-IVDA. Among the 24 couples of whom one or both partners were seropositive, concordance in HTLV-III seropositivity was present in 5/11 (45%) couples composed of both IVDA, and in only 1/13 (8%) couples composed of an IVDA and a non-IVDA. This suggests that the sharing of contaminated needles, universally practiced by our IVDA population, plays a more important role in the transmission of HTLV-III than sexual contact.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalAIDS Research
Volume2
Issue number4
Publication statusPublished - 1986

Fingerprint

Drug Users
HIV Infections
HIV Seropositivity
Sex Workers
Needle Sharing
Sex Work
Yugoslavia
Population Control
Sweat
Austria
Drug and Narcotic Control
Blood Donors
Italy
Hyperplasia
Fatigue
Acquired Immunodeficiency Syndrome
Lymph Nodes
Lymphadenopathy
HIV

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

HTLV-III infection among 315 intravenous drug abusers : Seroepidemiological, clinical, and pathological findings. / Tirelli, U.; Vaccher, E.; Carbone, A.; Diodato, S.; Sorio, R.; Bosio, R.; Tamburlini, R.; Crotti, D.; Crovatto, M.; De Paoli, P.

In: AIDS Research, Vol. 2, No. 4, 1986, p. 325-334.

Research output: Contribution to journalArticle

Tirelli, U, Vaccher, E, Carbone, A, Diodato, S, Sorio, R, Bosio, R, Tamburlini, R, Crotti, D, Crovatto, M & De Paoli, P 1986, 'HTLV-III infection among 315 intravenous drug abusers: Seroepidemiological, clinical, and pathological findings', AIDS Research, vol. 2, no. 4, pp. 325-334.
Tirelli, U. ; Vaccher, E. ; Carbone, A. ; Diodato, S. ; Sorio, R. ; Bosio, R. ; Tamburlini, R. ; Crotti, D. ; Crovatto, M. ; De Paoli, P. / HTLV-III infection among 315 intravenous drug abusers : Seroepidemiological, clinical, and pathological findings. In: AIDS Research. 1986 ; Vol. 2, No. 4. pp. 325-334.
@article{32c04db12fc140378ed66a12032d8f03,
title = "HTLV-III infection among 315 intravenous drug abusers: Seroepidemiological, clinical, and pathological findings",
abstract = "Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts' assistance in the Friuli Venezia-Ciulia region of Italy, close to the borders of Austria and Yugoslavia. No case of AIDS has been observed. Sixty-five (21{\%}) were affected by persistent generalized lymphadenopathy (PGL). HTLV-III seropositivity was noted in 86 (27{\%}) of the overall 315 IVDA, in 50 (77{\%}) of 65 patients with PGL, and in 1 (0.5{\%}) of 205 blood donors tested as a control group. Patients with PGL had a significantly lower OKT4/OKT8 ratio than the rest of the IVDA population and controls. Systemic symptoms were present in 52{\%} of the patients with PGL, the most frequent symptoms being fatigue and night sweats. In 20 patients with PGL, DR typing revealed a significant increase in DR-5 frequency and a significant decrease of DR-2 frequency. The predominant histological features in the lymph nodes taken from 25 patients consisted of an exuberant follicular hyperplasia, capillary vessel proliferation, and plasmacytosis. Nineteen (22{\%}) females reporting occasional prostitution were compared to 10 non-IVDA female prostitutes and concomitantly evaluated. HTLV-III seropositivity was noted in 11 (58{\%}) of 19 IVDA female prostitutes and in none of the 10 non-IVDA prostitutes. Thirty-five couples composed of both IVDA were compared to 24 couples composed of an IVDA and a non-IVDA. Among the 24 couples of whom one or both partners were seropositive, concordance in HTLV-III seropositivity was present in 5/11 (45{\%}) couples composed of both IVDA, and in only 1/13 (8{\%}) couples composed of an IVDA and a non-IVDA. This suggests that the sharing of contaminated needles, universally practiced by our IVDA population, plays a more important role in the transmission of HTLV-III than sexual contact.",
author = "U. Tirelli and E. Vaccher and A. Carbone and S. Diodato and R. Sorio and R. Bosio and R. Tamburlini and D. Crotti and M. Crovatto and {De Paoli}, P.",
year = "1986",
language = "English",
volume = "2",
pages = "325--334",
journal = "AIDS Research",
issn = "0737-6006",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - HTLV-III infection among 315 intravenous drug abusers

T2 - Seroepidemiological, clinical, and pathological findings

AU - Tirelli, U.

AU - Vaccher, E.

AU - Carbone, A.

AU - Diodato, S.

AU - Sorio, R.

AU - Bosio, R.

AU - Tamburlini, R.

AU - Crotti, D.

AU - Crovatto, M.

AU - De Paoli, P.

PY - 1986

Y1 - 1986

N2 - Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts' assistance in the Friuli Venezia-Ciulia region of Italy, close to the borders of Austria and Yugoslavia. No case of AIDS has been observed. Sixty-five (21%) were affected by persistent generalized lymphadenopathy (PGL). HTLV-III seropositivity was noted in 86 (27%) of the overall 315 IVDA, in 50 (77%) of 65 patients with PGL, and in 1 (0.5%) of 205 blood donors tested as a control group. Patients with PGL had a significantly lower OKT4/OKT8 ratio than the rest of the IVDA population and controls. Systemic symptoms were present in 52% of the patients with PGL, the most frequent symptoms being fatigue and night sweats. In 20 patients with PGL, DR typing revealed a significant increase in DR-5 frequency and a significant decrease of DR-2 frequency. The predominant histological features in the lymph nodes taken from 25 patients consisted of an exuberant follicular hyperplasia, capillary vessel proliferation, and plasmacytosis. Nineteen (22%) females reporting occasional prostitution were compared to 10 non-IVDA female prostitutes and concomitantly evaluated. HTLV-III seropositivity was noted in 11 (58%) of 19 IVDA female prostitutes and in none of the 10 non-IVDA prostitutes. Thirty-five couples composed of both IVDA were compared to 24 couples composed of an IVDA and a non-IVDA. Among the 24 couples of whom one or both partners were seropositive, concordance in HTLV-III seropositivity was present in 5/11 (45%) couples composed of both IVDA, and in only 1/13 (8%) couples composed of an IVDA and a non-IVDA. This suggests that the sharing of contaminated needles, universally practiced by our IVDA population, plays a more important role in the transmission of HTLV-III than sexual contact.

AB - Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts' assistance in the Friuli Venezia-Ciulia region of Italy, close to the borders of Austria and Yugoslavia. No case of AIDS has been observed. Sixty-five (21%) were affected by persistent generalized lymphadenopathy (PGL). HTLV-III seropositivity was noted in 86 (27%) of the overall 315 IVDA, in 50 (77%) of 65 patients with PGL, and in 1 (0.5%) of 205 blood donors tested as a control group. Patients with PGL had a significantly lower OKT4/OKT8 ratio than the rest of the IVDA population and controls. Systemic symptoms were present in 52% of the patients with PGL, the most frequent symptoms being fatigue and night sweats. In 20 patients with PGL, DR typing revealed a significant increase in DR-5 frequency and a significant decrease of DR-2 frequency. The predominant histological features in the lymph nodes taken from 25 patients consisted of an exuberant follicular hyperplasia, capillary vessel proliferation, and plasmacytosis. Nineteen (22%) females reporting occasional prostitution were compared to 10 non-IVDA female prostitutes and concomitantly evaluated. HTLV-III seropositivity was noted in 11 (58%) of 19 IVDA female prostitutes and in none of the 10 non-IVDA prostitutes. Thirty-five couples composed of both IVDA were compared to 24 couples composed of an IVDA and a non-IVDA. Among the 24 couples of whom one or both partners were seropositive, concordance in HTLV-III seropositivity was present in 5/11 (45%) couples composed of both IVDA, and in only 1/13 (8%) couples composed of an IVDA and a non-IVDA. This suggests that the sharing of contaminated needles, universally practiced by our IVDA population, plays a more important role in the transmission of HTLV-III than sexual contact.

UR - http://www.scopus.com/inward/record.url?scp=0022913513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022913513&partnerID=8YFLogxK

M3 - Article

C2 - 3814261

AN - SCOPUS:0022913513

VL - 2

SP - 325

EP - 334

JO - AIDS Research

JF - AIDS Research

SN - 0737-6006

IS - 4

ER -