HTLV-III infection among 315 intravenous drug abusers: Seroepidemiological, clinical, and pathological findings

U. Tirelli, E. Vaccher, A. Carbone, S. Diodato, R. Sorio, R. Bosio, R. Tamburlini, D. Crotti, M. Crovatto, P. De Paoli

Research output: Contribution to journalArticle

Abstract

Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts' assistance in the Friuli Venezia-Ciulia region of Italy, close to the borders of Austria and Yugoslavia. No case of AIDS has been observed. Sixty-five (21%) were affected by persistent generalized lymphadenopathy (PGL). HTLV-III seropositivity was noted in 86 (27%) of the overall 315 IVDA, in 50 (77%) of 65 patients with PGL, and in 1 (0.5%) of 205 blood donors tested as a control group. Patients with PGL had a significantly lower OKT4/OKT8 ratio than the rest of the IVDA population and controls. Systemic symptoms were present in 52% of the patients with PGL, the most frequent symptoms being fatigue and night sweats. In 20 patients with PGL, DR typing revealed a significant increase in DR-5 frequency and a significant decrease of DR-2 frequency. The predominant histological features in the lymph nodes taken from 25 patients consisted of an exuberant follicular hyperplasia, capillary vessel proliferation, and plasmacytosis. Nineteen (22%) females reporting occasional prostitution were compared to 10 non-IVDA female prostitutes and concomitantly evaluated. HTLV-III seropositivity was noted in 11 (58%) of 19 IVDA female prostitutes and in none of the 10 non-IVDA prostitutes. Thirty-five couples composed of both IVDA were compared to 24 couples composed of an IVDA and a non-IVDA. Among the 24 couples of whom one or both partners were seropositive, concordance in HTLV-III seropositivity was present in 5/11 (45%) couples composed of both IVDA, and in only 1/13 (8%) couples composed of an IVDA and a non-IVDA. This suggests that the sharing of contaminated needles, universally practiced by our IVDA population, plays a more important role in the transmission of HTLV-III than sexual contact.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalAIDS Research
Volume2
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Tirelli, U., Vaccher, E., Carbone, A., Diodato, S., Sorio, R., Bosio, R., Tamburlini, R., Crotti, D., Crovatto, M., & De Paoli, P. (1986). HTLV-III infection among 315 intravenous drug abusers: Seroepidemiological, clinical, and pathological findings. AIDS Research, 2(4), 325-334.