HTLV-V: A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia

Vittorio Manzari, Angela Gismondi, Giovanni Barillari, Stefania Morrone, Andrea Modesti, Loredana Albonici, Laura De Marchis, Vito Fazio, Angela Gradilone, Massimo Zani, Luigi Frati, Angela Santoni

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Abstract

A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/tymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of die patients proved to be at any apparent risk for HIV-1 infection. The name proposed for dus virus is HTLV-V, and die date indicate diat it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.

Original languageEnglish
Pages (from-to)1581-1583
Number of pages3
JournalScience
Volume238
Issue number4833
Publication statusPublished - 1987

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T-Cell Leukemia
T-Cell Lymphoma
Retroviridae
Human T-lymphotropic virus 1
HIV-1
Human T-lymphotropic virus 2
Cutaneous T-Cell Lymphoma
Tumor Cell Line
HIV Antigens
Deltaretrovirus
Proviruses
Mycosis Fungoides
Spouses
HIV Infections
Names
Lymphoma
Leukemia
Viruses
Phenotype
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Manzari, V., Gismondi, A., Barillari, G., Morrone, S., Modesti, A., Albonici, L., ... Santoni, A. (1987). HTLV-V: A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia. Science, 238(4833), 1581-1583.

HTLV-V : A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia. / Manzari, Vittorio; Gismondi, Angela; Barillari, Giovanni; Morrone, Stefania; Modesti, Andrea; Albonici, Loredana; De Marchis, Laura; Fazio, Vito; Gradilone, Angela; Zani, Massimo; Frati, Luigi; Santoni, Angela.

In: Science, Vol. 238, No. 4833, 1987, p. 1581-1583.

Research output: Contribution to journalArticle

Manzari, V, Gismondi, A, Barillari, G, Morrone, S, Modesti, A, Albonici, L, De Marchis, L, Fazio, V, Gradilone, A, Zani, M, Frati, L & Santoni, A 1987, 'HTLV-V: A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia', Science, vol. 238, no. 4833, pp. 1581-1583.
Manzari V, Gismondi A, Barillari G, Morrone S, Modesti A, Albonici L et al. HTLV-V: A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia. Science. 1987;238(4833):1581-1583.
Manzari, Vittorio ; Gismondi, Angela ; Barillari, Giovanni ; Morrone, Stefania ; Modesti, Andrea ; Albonici, Loredana ; De Marchis, Laura ; Fazio, Vito ; Gradilone, Angela ; Zani, Massimo ; Frati, Luigi ; Santoni, Angela. / HTLV-V : A new human retrovirus isolated in a tac-negative T cell lymphoma/leukemia. In: Science. 1987 ; Vol. 238, No. 4833. pp. 1581-1583.
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