HTLVI antibodies in multiple sclerosis and other neurological diseases.

P. Ferrante, M. Seresella, C. E. Cocuzza, D. Caputo, E. Cattaneo, G. Achilli, C. L. Cazzullo

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Abstract

The sera and the CSFs from 157 Multiple Sclerosis (MS) patients and 43 other neurological diseases (OND) cases have been evaluated for the presence of HTLVI antibodies. A commercial passive agglutination assay (PPA), an indirect fluorescence assay (IFA), and a Western Immunoblotting (WIB) performed in our laboratories have been employed. No OND samples showed HTLVI antibodies, while 14 sera and 1 CSF from MS patients resulted positive by PPA and 4 sera were positive with the IFA. When tested with WIB 6 MS sera showed a reactivity against one or more HTLVI proteins. Our results lead us to affirm that in a small number of MS patients, when sensitive tests are employed, it is possible to observe an antibody response toward proteins that share one or more epitope with HTLVI antigens.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalActa Neurologica
Volume12
Issue number1
Publication statusPublished - Feb 1990

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Ferrante, P., Seresella, M., Cocuzza, C. E., Caputo, D., Cattaneo, E., Achilli, G., & Cazzullo, C. L. (1990). HTLVI antibodies in multiple sclerosis and other neurological diseases. Acta Neurologica, 12(1), 95-99.