HTR2A gene variants and psychiatric disorders

A review of current literature and selection of SNPs for future studies

Alessandro Serretti, Antonio Drago, Diana De Ronchi

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Variants at the gene encoding for the 5-hydrosytryptamine (serotonin) receptor 2A (HTR2A) have been associated with many psychiatric disorders such as schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer's disease. The studied SNPs differ across studies, in the present review we focused on available evidence with the aim of identifying the overall phenotypic profile of HTR2A variant carriers. We then extensively analyzed all SNPs of the HTR2A gene with criteria of frequency, haplotype blocks, previous evidence, functionality in order to obtain a list of suitable SNPs for future studies that properly cover all possible genetic control of the HTR2A gene. Genetic association studies report conflicting and generally negative results. Most replicated data suggest C allele of the 102 T/C and Tyr452 variants as risk factor for psychosis and antipsychotic response, but the number of not replicating studies does not allow to draw any definite conclusion. Moreover their impact as risk factors is very small. In the other investigated psychiatric fields, evidence shows no involvement or at least a small and not replicated role for HTR2A gene variants. Conflicting and negative results could be due to a real marginal role of this receptor gene variants, or it could be caused by a lack of gene coverage of investigated SNPs. We suggest a wider investigation of the HTR2A gene to better understand its role in psychiatric disorders, preferably complemented with the use of proteomic or metabolomic approaches.

Original languageEnglish
Pages (from-to)2053-2069
Number of pages17
JournalCurrent Medicinal Chemistry
Volume14
Issue number19
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Single Nucleotide Polymorphism
Psychiatry
Genes
Receptor, Serotonin, 5-HT2A
Gene encoding
Metabolomics
Obsessive-Compulsive Disorder
Genetic Association Studies
Antipsychotic Agents
Attention Deficit Disorder with Hyperactivity
Anxiety Disorders
Mood Disorders
Psychotic Disorders
Proteomics
Suicide
Haplotypes
Schizophrenia
Alzheimer Disease
Alleles

Keywords

  • Depression
  • Gene
  • Mood disorders
  • Psychiatry
  • Schizophrenia
  • Serotonin

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

HTR2A gene variants and psychiatric disorders : A review of current literature and selection of SNPs for future studies. / Serretti, Alessandro; Drago, Antonio; De Ronchi, Diana.

In: Current Medicinal Chemistry, Vol. 14, No. 19, 08.2007, p. 2053-2069.

Research output: Contribution to journalArticle

Serretti, Alessandro ; Drago, Antonio ; De Ronchi, Diana. / HTR2A gene variants and psychiatric disorders : A review of current literature and selection of SNPs for future studies. In: Current Medicinal Chemistry. 2007 ; Vol. 14, No. 19. pp. 2053-2069.
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