HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer

Renato Franco, Francesca Collina, Maurizio Di Bonito, Gerardo Botti, Donatella Montanaro, Luigi Di Maio, Bruno Vincenzi, Gabriella Landi, Massimiliano D'aiuto, Michele Caraglia, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: HtrA1, a member of the High Temperature Requirement Factor A family of oxidative stress-response proteases seems to play a role as a tumor suppressor, being down-regulated in a series of human cancers during their progression. Particularly, low HtrA1 mRNA levels have been observed in breast cancer patients with more aggressive clinical features. These have been shown to relate to a longer disease free and overall survival, with more pronounced effects in axillary nodes positive patients. Subjects and Methods: We have analyzed for immunohistochemical HtrA1 expression a series of 66 sentinel node positive breast cancers through Tissue Micro Array technology. Results: HtrA1 was absent to low in 29 cases, medium in 19 cases and high in 18 cases. Our data revealed a positive significant relation between HtrA1 expression level and estrogen (p=0,002) and progestinic receptor expression (p=0.003) and a negative correlation with histological grading (p=0.028), proliferation index (p=0.05), common BC histotypes (p=0.040), luminal A and B subtypes (p=0.001), metastasis development (p

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalHistology and Histopathology
Volume30
Issue number6
DOIs
Publication statusPublished - 2015

Keywords

  • Breast cancer
  • HtrA1
  • Tissue microarray
  • Tumor suppressor

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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