hu-PBL-SCID mice: An in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease

M. T. Fuzzati-Armentero

Research output: Contribution to journalArticle

Abstract

The Epstein-Barr virus (EBV) exists in most humans as a lifelong latent infection established in host B cells after a primary viral encounter. In immunosuppressed individuals, such as post-transplant patients, the presence of EBV-infected B cells may lead to lymphoproliferative disease. Injection of human peripheral blood lymphocytes from EBV-positive donors into mice with severe combined immunodeficiency induces human lymphoproliferative disease in the recipient closely resembling that of human posttransplant patients. This xenochimeric human-mouse model is increasingly being used to elucidate the mechanisms of EBV-specific lymphomagenesis and to assess novel therapeutic approaches.

Original languageEnglish
Pages (from-to)155-168
Number of pages14
JournalHistology and Histopathology
Volume13
Issue number1
Publication statusPublished - 1998

Keywords

  • Epstein-Barr virus
  • hu-PBL-SCID mouse
  • Lymphoproliferative disease

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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