Huge renal cyst with parietal renal cell carcinoma, osseous metaplasia and a papillary adenoma: A case report with unique clinicopathological features and literature review

Giacomo Puppa, Andrea Gervasio, Kutsal Yorukoglu, Romano Colombari, Francesco De Marchi, Vincenzo Canzonieri

Research output: Contribution to journalArticle


The unique clinicopathological features of a giant solitary renal cyst with a parietal clear cell carcinoma in contiguity with a focus of osseous metaplasia and a papillary adenoma are reported. Ultrasonography and computed tomography showed a single cyst with a focal wall irregularity. During surgery, a frozen section revealed the presence of a renal cell carcinoma of clear cell type, so a nephrectomy was performed. After extensive pathological sampling of the cyst's wall, a focus of osseous metaplasia in contiguity with the main tumour and a microscopic papillary adenoma were found. Diagnostic implications for the present case are discussed within a pertinent literature review.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalVirchows Archiv
Issue number3
Publication statusPublished - Mar 2008



  • Cyst
  • Osseous metaplasia
  • Papillary adenoma
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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