Expression and shedding of Ia-like antigens were evaluated in human cell lines treated with β-type interferon. A significant and dose-dependent increase in the amount of cell-associated antigens was found that reached a peak after 48 h of interferon treatment. An increased accumulation of Ia antigens in the culture fluids was also observed. Similar increases in the expression and shedding of HLA-A,B,C and β2-microglobulin were observed. Human α-type interferon caused enhanced expression as well as enhanced shedding of HLA-A,B,C and β2-microglobulin, but was ineffective with respect to Ia expression.
- Ia antigens
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