Human β-type interferon enhances the expression and shedding of Ia-like antigens. Comparison to HLA-A,B,C and β2-microglobulin

Antonina Dolei, Franco Ameglio, Maria R. Capobianchi, Roberto Tosi

Research output: Contribution to journalArticle

Abstract

Expression and shedding of Ia-like antigens were evaluated in human cell lines treated with β-type interferon. A significant and dose-dependent increase in the amount of cell-associated antigens was found that reached a peak after 48 h of interferon treatment. An increased accumulation of Ia antigens in the culture fluids was also observed. Similar increases in the expression and shedding of HLA-A,B,C and β2-microglobulin were observed. Human α-type interferon caused enhanced expression as well as enhanced shedding of HLA-A,B,C and β2-microglobulin, but was ineffective with respect to Ia expression.

Original languageEnglish
Pages (from-to)367-381
Number of pages15
JournalAntiviral Research
Volume1
Issue number6
DOIs
Publication statusPublished - 1982

Keywords

  • HLA-A,B,C
  • Ia antigens
  • interferon
  • β-microglobulin

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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