Human β2-defensin in oral lichen planus expresses the degree of inflammation

L Azzi, P Moretto, R Vinci, F Croveri, A Boggio, J Silvestre-Rangil, L Tettamanti, A Tagliabue, Alberto Passi

Research output: Contribution to journalArticle

Abstract

In this work, it was decided to study the role of HBD-2, an inducible and not constitutionally expressed defensin, in the pathogenesis of Oral Lichen Planus (OLP) and of Burning Mouth Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease , were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. There was no statistically significant difference between the groups (p=0.523; p=0.897). However, patients affected by OLP showed a dycotomic distribution of values: While 10 of them showed similar values to those found out in the other two groups, 7 patients expressed high levels of HBD-2, and 3500 pg/ml was the threshold to distinguish the subgroups. During the dental visit the clinician classified OLP patients into two groups according to the clinical presentation of the disease: Reticular and hyperplastic (white OLP), atrophic and erosive forms (red OLP). There was a statistical significant correlation between the clinical and numeric classification of the patients (p=0.004; p=0.001), and the expression of HBD-2 was higher in the red OLP group than in the white OLP group (p=0.000; p=0.000). In conclusion, this study shows that HBD-2 represents an index to assess active inflammation and it is probably linked to the presence of the typical band-like CD8+ infiltrate in Oral Lichen Planus. © Copyright by BIOLIFE, s.a.s.
Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalJournal of Biological Regulators and Homeostatic Agents
Volume31
Issue number2, Suppl.1
Publication statusPublished - 2017

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Oral Lichen Planus
Defensins
Inflammation
Burning Mouth Syndrome
Saliva
Tooth

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Azzi, L., Moretto, P., Vinci, R., Croveri, F., Boggio, A., Silvestre-Rangil, J., ... Passi, A. (2017). Human β2-defensin in oral lichen planus expresses the degree of inflammation. Journal of Biological Regulators and Homeostatic Agents, 31(2, Suppl.1), 77-87.

Human β2-defensin in oral lichen planus expresses the degree of inflammation. / Azzi, L; Moretto, P; Vinci, R; Croveri, F; Boggio, A; Silvestre-Rangil, J; Tettamanti, L; Tagliabue, A; Passi, Alberto.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 31, No. 2, Suppl.1, 2017, p. 77-87.

Research output: Contribution to journalArticle

Azzi, L, Moretto, P, Vinci, R, Croveri, F, Boggio, A, Silvestre-Rangil, J, Tettamanti, L, Tagliabue, A & Passi, A 2017, 'Human β2-defensin in oral lichen planus expresses the degree of inflammation', Journal of Biological Regulators and Homeostatic Agents, vol. 31, no. 2, Suppl.1, pp. 77-87.
Azzi L, Moretto P, Vinci R, Croveri F, Boggio A, Silvestre-Rangil J et al. Human β2-defensin in oral lichen planus expresses the degree of inflammation. Journal of Biological Regulators and Homeostatic Agents. 2017;31(2, Suppl.1):77-87.
Azzi, L ; Moretto, P ; Vinci, R ; Croveri, F ; Boggio, A ; Silvestre-Rangil, J ; Tettamanti, L ; Tagliabue, A ; Passi, Alberto. / Human β2-defensin in oral lichen planus expresses the degree of inflammation. In: Journal of Biological Regulators and Homeostatic Agents. 2017 ; Vol. 31, No. 2, Suppl.1. pp. 77-87.
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AB - In this work, it was decided to study the role of HBD-2, an inducible and not constitutionally expressed defensin, in the pathogenesis of Oral Lichen Planus (OLP) and of Burning Mouth Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease , were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. There was no statistically significant difference between the groups (p=0.523; p=0.897). However, patients affected by OLP showed a dycotomic distribution of values: While 10 of them showed similar values to those found out in the other two groups, 7 patients expressed high levels of HBD-2, and 3500 pg/ml was the threshold to distinguish the subgroups. During the dental visit the clinician classified OLP patients into two groups according to the clinical presentation of the disease: Reticular and hyperplastic (white OLP), atrophic and erosive forms (red OLP). There was a statistical significant correlation between the clinical and numeric classification of the patients (p=0.004; p=0.001), and the expression of HBD-2 was higher in the red OLP group than in the white OLP group (p=0.000; p=0.000). In conclusion, this study shows that HBD-2 represents an index to assess active inflammation and it is probably linked to the presence of the typical band-like CD8+ infiltrate in Oral Lichen Planus. © Copyright by BIOLIFE, s.a.s.

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