Human γδ T cells: A nonredundant system in the immune-surveillance against cancer

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Abstract

Down-regulation of expression of MHC alleles, as well as tumor-specific antigens, is observed frequently during tumor progression, resulting in an impairment of MHC-restricted, αβ-T-cell-mediated, tumor-specific immunity. Given the unique set of antigens recognized and the lack of requirement for classical antigen-presenting molecules, γδ T cells might, therefore, represent a nonredundant system in anticancer surveillance, as proposed for the immune response against pathogens. Evidence that γδ and αβ T cells make distinct contributions to anticancer surveillance has been provided recently in mice. Here, we discuss the potential role played by resident V δ1+ and circulating V δ2+ T cells in the defense against solid tumors and hematological malignancies.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalTrends in Immunology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2002

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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