Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma

Luisella Righi; Ida Rapa; Arianna Votta; Mauro Papotti; Anna Sapino

doi:10.1007/s00428-012-1223-1

Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma

Luisella Righi, Ida Rapa, Arianna Votta, Mauro Papotti, Anna Sapino

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroendocrine (NE) breast carcinoma is defined by morphological features similar to those of NE tumors of other organs and NE marker expression in at least 50 % of neoplastic cells. However, a NE morphology may be observed even in breast carcinomas lacking NE markers. Human achaete-scute homolog-1 (hASH-1) is a transcription factor that plays a key role in the regulation of mammalian neural and NE cell development and has been identified in several human NE tumors. The aim of this study was to investigate hASH-1 expression in human breast cancers. hASH-1 expression was evaluated in 482 consecutive non-NE invasive breast carcinomas, in a series of 84 breast cancers with >50 % NE marker expression (high NE differentiation) and 21 carcinomas with NE histology but negative or focally (

Original language	English
Pages (from-to)	415-421
Number of pages	7
Journal	Virchows Archiv
Volume	460
Issue number	4
DOIs	https://doi.org/10.1007/s00428-012-1223-1
Publication status	Published - Apr 2012

Keywords

Breast cancer
Chromogranin
hASH1
Neuroendocrine phenotype
Synaptophysin

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cell Biology
Molecular Biology

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title = "Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma",

abstract = "Neuroendocrine (NE) breast carcinoma is defined by morphological features similar to those of NE tumors of other organs and NE marker expression in at least 50 % of neoplastic cells. However, a NE morphology may be observed even in breast carcinomas lacking NE markers. Human achaete-scute homolog-1 (hASH-1) is a transcription factor that plays a key role in the regulation of mammalian neural and NE cell development and has been identified in several human NE tumors. The aim of this study was to investigate hASH-1 expression in human breast cancers. hASH-1 expression was evaluated in 482 consecutive non-NE invasive breast carcinomas, in a series of 84 breast cancers with >50 % NE marker expression (high NE differentiation) and 21 carcinomas with NE histology but negative or focally (",

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AU - Rapa, Ida

AU - Votta, Arianna

AU - Papotti, Mauro

AU - Sapino, Anna

PY - 2012/4

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N2 - Neuroendocrine (NE) breast carcinoma is defined by morphological features similar to those of NE tumors of other organs and NE marker expression in at least 50 % of neoplastic cells. However, a NE morphology may be observed even in breast carcinomas lacking NE markers. Human achaete-scute homolog-1 (hASH-1) is a transcription factor that plays a key role in the regulation of mammalian neural and NE cell development and has been identified in several human NE tumors. The aim of this study was to investigate hASH-1 expression in human breast cancers. hASH-1 expression was evaluated in 482 consecutive non-NE invasive breast carcinomas, in a series of 84 breast cancers with >50 % NE marker expression (high NE differentiation) and 21 carcinomas with NE histology but negative or focally (

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