Abstract
Neuroendocrine (NE) breast carcinoma is defined by morphological features similar to those of NE tumors of other organs and NE marker expression in at least 50 % of neoplastic cells. However, a NE morphology may be observed even in breast carcinomas lacking NE markers. Human achaete-scute homolog-1 (hASH-1) is a transcription factor that plays a key role in the regulation of mammalian neural and NE cell development and has been identified in several human NE tumors. The aim of this study was to investigate hASH-1 expression in human breast cancers. hASH-1 expression was evaluated in 482 consecutive non-NE invasive breast carcinomas, in a series of 84 breast cancers with >50 % NE marker expression (high NE differentiation) and 21 carcinomas with NE histology but negative or focally (
Original language | English |
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Pages (from-to) | 415-421 |
Number of pages | 7 |
Journal | Virchows Archiv |
Volume | 460 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2012 |
Keywords
- Breast cancer
- Chromogranin
- hASH1
- Neuroendocrine phenotype
- Synaptophysin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology
- Molecular Biology