Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma

Luisella Righi, Ida Rapa, Arianna Votta, Mauro Papotti, Anna Sapino

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine (NE) breast carcinoma is defined by morphological features similar to those of NE tumors of other organs and NE marker expression in at least 50 % of neoplastic cells. However, a NE morphology may be observed even in breast carcinomas lacking NE markers. Human achaete-scute homolog-1 (hASH-1) is a transcription factor that plays a key role in the regulation of mammalian neural and NE cell development and has been identified in several human NE tumors. The aim of this study was to investigate hASH-1 expression in human breast cancers. hASH-1 expression was evaluated in 482 consecutive non-NE invasive breast carcinomas, in a series of 84 breast cancers with >50 % NE marker expression (high NE differentiation) and 21 carcinomas with NE histology but negative or focally (

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalVirchows Archiv
Volume460
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Breast cancer
  • Chromogranin
  • hASH1
  • Neuroendocrine phenotype
  • Synaptophysin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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