Human autologous mixed lymphocyte reactions - A review

Francesco Indiveri, Andrea Barabino, Ivana Pierri, Vincenzo Grifoni

Research output: Contribution to journalArticlepeer-review

Abstract

The literature concerning the autologous mixed lymphocyte reactions has been reviewed. This analysis supports the following conclusions: human subjects have self-responsive cells which are capable of proliferating when co-cultured with irradiated autologous non-T or Ia+ T cells. Since monoclonal antibodies recognizing distinct determinants of Ia antigen have different effects on AMLR with non-T cells and on Ia+ type AMLR, there is the possibility that different Ia molecule determinants have different functional role in the process of cell-to-cell interaction. The presence of AMLR abnormalities in disease strongly suggests that reactivity among different cell subsets plays a role in immunological homeostasis.

Original languageEnglish
Pages (from-to)397-409
Number of pages13
JournalLa Ricerca in Clinica e in Laboratorio
Volume13
Issue number4
DOIs
Publication statusPublished - Oct 1983

Keywords

  • Antibodies
  • Autologous mixed lymphocyte reactions
  • Cell-to-cell interaction
  • Ia antigens
  • Immune response
  • Immunology
  • Monoclonal antibodies
  • Neoplastic diseases
  • T lymphocytes

ASJC Scopus subject areas

  • Clinical Biochemistry

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