Abstract
The literature concerning the autologous mixed lymphocyte reactions has been reviewed. This analysis supports the following conclusions: human subjects have self-responsive cells which are capable of proliferating when co-cultured with irradiated autologous non-T or Ia+ T cells. Since monoclonal antibodies recognizing distinct determinants of Ia antigen have different effects on AMLR with non-T cells and on Ia+ type AMLR, there is the possibility that different Ia molecule determinants have different functional role in the process of cell-to-cell interaction. The presence of AMLR abnormalities in disease strongly suggests that reactivity among different cell subsets plays a role in immunological homeostasis.
Original language | English |
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Pages (from-to) | 397-409 |
Number of pages | 13 |
Journal | La Ricerca in Clinica e in Laboratorio |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 1983 |
Keywords
- Antibodies
- Autologous mixed lymphocyte reactions
- Cell-to-cell interaction
- Ia antigens
- Immune response
- Immunology
- Monoclonal antibodies
- Neoplastic diseases
- T lymphocytes
ASJC Scopus subject areas
- Clinical Biochemistry