TY - JOUR
T1 - Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events
AU - Aranburu, Alaitz
AU - Piano Mortari, Eva
AU - Baban, Anwar
AU - Giorda, Ezio
AU - Cascioli, Simona
AU - Marcellini, Valentina
AU - Scarsella, Marco
AU - Ceccarelli, Sara
AU - Corbelli, Sandro
AU - Cantarutti, Nicoletta
AU - De Vito, Rita
AU - Inserra, Alessandro
AU - Nicolosi, Luciana
AU - Lanfranchi, Arnalda
AU - Porta, Fulvio
AU - Cancrini, Caterina
AU - Finocchi, Andrea
AU - Carsetti, Rita
PY - 2016
Y1 - 2016
N2 - Switched and IgM memory B cells execute different and noninterchangeable functions. We studied memory B cells in children of different ages, in peripheral blood and spleen and compared them with those of children born asplenic or unable to build germinal centers. We show that, whereas switched memory B cells are mostly generated in the germinal centers at all ages, IgM memory B cells can be distinct in three types with different developmental history. Innate IgM memory B cells, the largest pool in infants, are generated in the spleen by a germinal center-independent mechanism. With age, if the spleen is present and germinal centers are functional, innate IgM memory B cells are remodelled and accumulate somatic mutations. The third type of IgM memory B cell is a by-product of the germinal center reaction. Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life.
AB - Switched and IgM memory B cells execute different and noninterchangeable functions. We studied memory B cells in children of different ages, in peripheral blood and spleen and compared them with those of children born asplenic or unable to build germinal centers. We show that, whereas switched memory B cells are mostly generated in the germinal centers at all ages, IgM memory B cells can be distinct in three types with different developmental history. Innate IgM memory B cells, the largest pool in infants, are generated in the spleen by a germinal center-independent mechanism. With age, if the spleen is present and germinal centers are functional, innate IgM memory B cells are remodelled and accumulate somatic mutations. The third type of IgM memory B cell is a by-product of the germinal center reaction. Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life.
KW - Antibodies
KW - B cell development
KW - B cells
KW - Immunoglobulins
KW - Innate immunity
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U2 - 10.1002/eji.201646642
DO - 10.1002/eji.201646642
M3 - Article
AN - SCOPUS:85007247376
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
ER -