Human bone disorders: Pathological role and diagnostic potential of matrix metalloproteinases

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bone undergoes continuous remodeling under physiological and pathological conditions. Failure of the regulation of this process leads to several disorders involving bone erosion. This series of events is mainly based on the action of proteinases, particularly matrix metalloproteinases (MMPs). MMPs have been recently suggested as potential bone resorption markers which could be added to the commonly used ones, in order to predict outcome of disease processes and healing, and to monitor disease response to treatment. As for classical biochemical bone markers, MMPs are far from being applied in primary clinical diagnosis, but they could be promising in some cases for disease prognosis. MMPs as bone remodeling biomarkers could provide information that boosts our understanding of the prognosis, disease activity and pathogenesis of bone disorders. Clarifying the MMPs' role in bone remodeling and healing could potentially help predict disease progression and the effects of direct specific therapy.

Original languageEnglish
Pages (from-to)1590-1593
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Matrix Metalloproteinases
Bone
Bone and Bones
Bone Remodeling
Biomarkers
Bone Matrix
Bone Resorption
Disease Progression
Peptide Hydrolases
Erosion
Therapeutics

Keywords

  • Bone disorders
  • Bone remodeling
  • Diagnostic biomarkers
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

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abstract = "Bone undergoes continuous remodeling under physiological and pathological conditions. Failure of the regulation of this process leads to several disorders involving bone erosion. This series of events is mainly based on the action of proteinases, particularly matrix metalloproteinases (MMPs). MMPs have been recently suggested as potential bone resorption markers which could be added to the commonly used ones, in order to predict outcome of disease processes and healing, and to monitor disease response to treatment. As for classical biochemical bone markers, MMPs are far from being applied in primary clinical diagnosis, but they could be promising in some cases for disease prognosis. MMPs as bone remodeling biomarkers could provide information that boosts our understanding of the prognosis, disease activity and pathogenesis of bone disorders. Clarifying the MMPs' role in bone remodeling and healing could potentially help predict disease progression and the effects of direct specific therapy.",
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