Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice

Marina Morigi, Martino Introna, Barbara Imberti, Daniela Corna, Mauro Abbate, Cinzia Rota, Daniela Rottoli, Ariela Benigni, Norberto Perico, Carla Zoja, Alessandro Rambaldi, Andrea Remuzzi, Giuseppe Remuzzia

Research output: Contribution to journalArticlepeer-review


Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from rodents has been identified as a strategy for renal repair in experimental models of acute kidney injury (AKI), a highly life-threatening clinical setting. The therapeutic potential of BM-MSC of human origin has not been reported so far. Here, we investigated whether human BM-MSC treatment could prevent AKI induced by cisplatin and prolong survival in an immunodeficient mouse model. Results showed that human BM-MSC infusion decreased proximal tubular epithelial cell injury and ameliorated the deficit in renal function, resulting in reduced recipient mortality. Infused BM-MSC became localized predominantly in peritubular areas and acted to reduce renal cell apoptosis and to increase proliferation. BM-MSC also induced protection against AKI-related peritubular capillary changes consisting of endothelial cell abnormalities, leukocyte infiltration, and low endothelial cell and lumen volume density as assessed by morphometric analysis. These findings indicate that human MSC of bone marrow origin hold potential to prolong survival in AKI and should be considered for testing in a clinical trial.

Original languageEnglish
Pages (from-to)2075-2082
Number of pages8
JournalStem Cells
Issue number8
Publication statusPublished - Aug 2008


  • Acute renal failure
  • Human mesenchymal stem cells
  • Kidney repair
  • Tubular cells

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine


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