Human brain cortical correlates of short-latency afferent inhibition: A combined EEG-TMS study

Florinda Ferreri, David Ponzo, Taina Hukkanen, Esa Mervaala, Mervi Könönen, Patrizio Pasqualetti, Fabrizio Vecchio, Paolo Maria Rossini, Sara Määttä

Research output: Contribution to journalArticle

Abstract

When linking in time electrical stimulation of the peripheral nerve with transcranial magnetic stimulation (TMS), the excitability of the motor cortex can be modulated to evoke clear inhibition, as reflected by the amplitude decrement in the motor-evoked potentials (MEPs). This specific property, designated short-latency afferent inhibition (SAI), occurs when the nerve-TMS interstimulus interval (ISI) is approximately 25 ms and is considered to be a corticothalamic phenomenon. The aim of the present study was to use the electroencephalographic (EEG) responses to navigated-TMS coregistration to better characterize the neuronal circuits underlying SAI. The present experimental set included magnetic resonance imaging (MRI)-navigated TMS and 60- channel TMS-compatible EEG devices. TMS-evoked EEG responses and MEPs were analyzed in eight healthy volunteers; ISIs between median nerve and cortical stimulation were determined relative to the latency of the individual N20 component of the somatosensoryevoked potential (SEP) obtained after stimulation of the median nerve. ISIs from the latency of the N20 plus 3 ms and N20 plus 10 ms were investigated. In all experimental conditions, TMS-evoked EEG responses were characterized by a sequence of negative deflections peaking at approximately 7, 44, and 100 ms alternating with positive peaks at approximately 30, 60, and 180 ms post-TMS. Moreover, ISI N20+3 ms modulated both EEG-evoked activity and MEPs. In particular, it inhibited MEP amplitudes, attenuated cortical P60 and N100 responses, and induced motor cortex beta rhythm selective decrement of phase locking. The findings of the present experiment suggest the cortical origin of SAI that could result from the cortico- cortical activation of GABAergic-mediated inhibition onto the corticospinal neurons modulated by cholinergic activation able to reducing intralaminar inhibition and promoting intracolumnar inhibition.

Original languageEnglish
Pages (from-to)314-323
Number of pages10
JournalJournal of Neurophysiology
Volume108
Issue number1
DOIs
Publication statusPublished - Jul 1 2012

Keywords

  • EEG
  • EEG-TMS coregistration
  • Navigated transcranial magnetic stimulation
  • SAI

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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    Ferreri, F., Ponzo, D., Hukkanen, T., Mervaala, E., Könönen, M., Pasqualetti, P., Vecchio, F., Rossini, P. M., & Määttä, S. (2012). Human brain cortical correlates of short-latency afferent inhibition: A combined EEG-TMS study. Journal of Neurophysiology, 108(1), 314-323. https://doi.org/10.1152/jn.00796.2011