TY - JOUR
T1 - Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task
AU - Calandra-Buonaura, Giovanna
AU - Basso, Gianpaolo
AU - Gorno-Tempini, Maria Luisa
AU - Serafini, Marco
AU - Pagnoni, Giuseppe
AU - Baraldi, Patrizia
AU - Porro, Carlo Alberto
AU - Nichelli, Paolo
PY - 2002/10
Y1 - 2002/10
N2 - The purpose of this study was to validate a functional magnetic resonance imaging (fMRI) paradigm to activate both anterior and posterior language areas while collecting accuracy and reaction time data on subjects' performance. The paradigm was based on alternating graphemic and lexical decision tasks. In line with the classical model of language organisation, based on lesion data, and with the results of previous neuroimaging studies, cortical activation associated with lexical decision-making was strongly lateralised to the left hemisphere and involved a network of regions in the frontal, temporal and parietal lobes. Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies.
AB - The purpose of this study was to validate a functional magnetic resonance imaging (fMRI) paradigm to activate both anterior and posterior language areas while collecting accuracy and reaction time data on subjects' performance. The paradigm was based on alternating graphemic and lexical decision tasks. In line with the classical model of language organisation, based on lesion data, and with the results of previous neuroimaging studies, cortical activation associated with lexical decision-making was strongly lateralised to the left hemisphere and involved a network of regions in the frontal, temporal and parietal lobes. Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies.
KW - Functional magnetic resonance
KW - Graphemic decision
KW - Language mapping
KW - Lexical decision
UR - http://www.scopus.com/inward/record.url?scp=0036821225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036821225&partnerID=8YFLogxK
M3 - Article
C2 - 12675261
AN - SCOPUS:0036821225
VL - 17
SP - 183
EP - 191
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 4
ER -