Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task

Giovanna Calandra-Buonaura, Gianpaolo Basso, Maria Luisa Gorno-Tempini, Marco Serafini, Giuseppe Pagnoni, Patrizia Baraldi, Carlo Alberto Porro, Paolo Nichelli

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to validate a functional magnetic resonance imaging (fMRI) paradigm to activate both anterior and posterior language areas while collecting accuracy and reaction time data on subjects' performance. The paradigm was based on alternating graphemic and lexical decision tasks. In line with the classical model of language organisation, based on lesion data, and with the results of previous neuroimaging studies, cortical activation associated with lexical decision-making was strongly lateralised to the left hemisphere and involved a network of regions in the frontal, temporal and parietal lobes. Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies.

Original languageEnglish
Pages (from-to)183-191
Number of pages9
JournalFunctional Neurology
Volume17
Issue number4
Publication statusPublished - Oct 2002

Fingerprint

Language
Magnetic Resonance Imaging
Brain
Activation Analysis
Parietal Lobe
Frontal Lobe
Temporal Lobe
Neuroimaging
Decision Making
Clinical Studies

Keywords

  • Functional magnetic resonance
  • Graphemic decision
  • Language mapping
  • Lexical decision

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task. / Calandra-Buonaura, Giovanna; Basso, Gianpaolo; Gorno-Tempini, Maria Luisa; Serafini, Marco; Pagnoni, Giuseppe; Baraldi, Patrizia; Porro, Carlo Alberto; Nichelli, Paolo.

In: Functional Neurology, Vol. 17, No. 4, 10.2002, p. 183-191.

Research output: Contribution to journalArticle

Calandra-Buonaura, G, Basso, G, Gorno-Tempini, ML, Serafini, M, Pagnoni, G, Baraldi, P, Porro, CA & Nichelli, P 2002, 'Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task', Functional Neurology, vol. 17, no. 4, pp. 183-191.
Calandra-Buonaura, Giovanna ; Basso, Gianpaolo ; Gorno-Tempini, Maria Luisa ; Serafini, Marco ; Pagnoni, Giuseppe ; Baraldi, Patrizia ; Porro, Carlo Alberto ; Nichelli, Paolo. / Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task. In: Functional Neurology. 2002 ; Vol. 17, No. 4. pp. 183-191.
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