Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin

Alessandra Rossini, Caterina Frati, Costanza Lagrasta, Gallia Graiani, Alessandro Scopece, Stefano Cavalli, Ezio Musso, Marco Baccarin, Marina Di Segni, Francesco Fagnoni, Antonia Germani, Eugenio Quaini, Manuel Mayr, Qingbo Xu, Andrea Barbuti, Dario Difrancesco, Giulio Pompilio, Federico Quaini, Carlo Gaetano, Maurizio C. Capogrossi

Research output: Contribution to journalArticlepeer-review

Abstract

AimsBone marrow mesenchymal stromal cell (BMStC) transplantation into the infarcted heart improves left ventricular function and cardiac remodelling. However, it has been suggested that tissue-specific cells may be better for cardiac repair than cells from other sources. The objective of the present work has been the comparison of in vitro and in vivo properties of adult human cardiac stromal cells (CStC) to those of syngeneic BMStC.Methods and resultsAlthough CStC and BMStC exhibited a similar immunophenotype, their gene, microRNA, and protein expression profiles were remarkably different. Biologically, CStC, compared with BMStC, were less competent in acquiring the adipogenic and osteogenic phenotype but more efficiently expressed cardiovascular markers. When injected into the heart, in rat a model of chronic myocardial infarction, CStC persisted longer within the tissue, migrated into the scar, and differentiated into adult cardiomyocytes better than BMStC.ConclusionOur findings demonstrate that although CStC and BMStC share a common stromal phenotype, CStC present cardiovascular-associated features and may represent an important cell source for more efficient cardiac repair.

Original languageEnglish
Pages (from-to)650-660
Number of pages11
JournalCardiovascular Research
Volume89
Issue number3
DOIs
Publication statusPublished - Feb 15 2011

Keywords

  • Cardiac and bone marrow stromal cells
  • Cardiac regeneration
  • Cardiovascular differentiation
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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