Human CD4+ regulatory T cells and activation-induced tolerance

Ehud Hauben, Maria Grazia Roncarolo

Research output: Contribution to journalArticlepeer-review

Abstract

In the past years growing attention has been given to the role of regulatory T (Tr) cells in inducing and monitoring peripheral tolerance. Various subsets of Tr cells have been described based on their surface phenotype and cytokine production. However, presently there are no specific reliable markers for any of the Tr subsets and their classification is based predominantly upon their mode of suppression. In addition, the molecular mechanisms underlying the induction and mode of action of all Tr cell subsets remain to be elucidated. Here we review recent developments regarding human CD4+ Tr cells, their origin, phenotype, antigen specificity and mode of suppression.

Original languageEnglish
Pages (from-to)1023-1032
Number of pages10
JournalMicrobes and Infection
Volume7
Issue number7-8
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Autoimmunity
  • Beneficial
  • Detrimental
  • Immune homeostasis
  • Peripheral tolerance
  • Tr1 cells
  • Transplantation

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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