Human cingulate cortex and autonomic control: Converging neuroimaging and clinical evidence

Hugo D. Critchley, Christopher J. Mathias, Oliver Josephs, John O'Doherty, Sergio Zanini, Bonnie Kate Dewar, Lisa Cipolotti, Tim Shallice, Raymond J. Dolan

Research output: Contribution to journalArticle

Abstract

Human anterior cingulate function has been explained primarily within a cognitive framework. We used functional MRI experiments with simultaneous electrocardiography to examine regional brain activity associated with autonomic cardiovascular control during performance of cognitive and motor tasks. Using indices of heart rate variability, and high- and low-frequency power in the cardiac rhythm, we observed activity in the dorsal anterior cingulate cortex (ACC) related to sympathetic modulation of heart rate that was dissociable from cognitive and motor-related activity. The findings predict that during effortful cognitive and motor behaviour the dorsal ACC supports the generation of associated autonomic states of cardiovascular arousal. We subsequently tested this prediction by studying three patients with focal damage involving the ACC while they performed effortful cognitive and motor tests. Each showed abnormalities in autonomic cardiovascular responses with blunted autonomic arousal to mental stress when compared with 147 normal subjects tested in identical fashion. Thus, converging neuroimaging and clinical findings suggest that ACC function mediates context-driven modulation of bodily arousal states.

Original languageEnglish
Pages (from-to)2139-2152
Number of pages14
JournalBrain
Volume126
Issue number10
DOIs
Publication statusPublished - Oct 2003

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Gyrus Cinguli
Neuroimaging
Arousal
Heart Rate
Electrocardiography
Motor Activity
Magnetic Resonance Imaging
Brain

Keywords

  • Autonomic
  • Cingulate cortex
  • Cognition
  • Heart rate
  • Sympathetic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Critchley, H. D., Mathias, C. J., Josephs, O., O'Doherty, J., Zanini, S., Dewar, B. K., ... Dolan, R. J. (2003). Human cingulate cortex and autonomic control: Converging neuroimaging and clinical evidence. Brain, 126(10), 2139-2152. https://doi.org/10.1093/brain/awg216

Human cingulate cortex and autonomic control : Converging neuroimaging and clinical evidence. / Critchley, Hugo D.; Mathias, Christopher J.; Josephs, Oliver; O'Doherty, John; Zanini, Sergio; Dewar, Bonnie Kate; Cipolotti, Lisa; Shallice, Tim; Dolan, Raymond J.

In: Brain, Vol. 126, No. 10, 10.2003, p. 2139-2152.

Research output: Contribution to journalArticle

Critchley, HD, Mathias, CJ, Josephs, O, O'Doherty, J, Zanini, S, Dewar, BK, Cipolotti, L, Shallice, T & Dolan, RJ 2003, 'Human cingulate cortex and autonomic control: Converging neuroimaging and clinical evidence', Brain, vol. 126, no. 10, pp. 2139-2152. https://doi.org/10.1093/brain/awg216
Critchley HD, Mathias CJ, Josephs O, O'Doherty J, Zanini S, Dewar BK et al. Human cingulate cortex and autonomic control: Converging neuroimaging and clinical evidence. Brain. 2003 Oct;126(10):2139-2152. https://doi.org/10.1093/brain/awg216
Critchley, Hugo D. ; Mathias, Christopher J. ; Josephs, Oliver ; O'Doherty, John ; Zanini, Sergio ; Dewar, Bonnie Kate ; Cipolotti, Lisa ; Shallice, Tim ; Dolan, Raymond J. / Human cingulate cortex and autonomic control : Converging neuroimaging and clinical evidence. In: Brain. 2003 ; Vol. 126, No. 10. pp. 2139-2152.
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