Human class I supertypes and CTL repertoires extend to chimpanzees

Roberto Bertoni, Alessandro Sette, John Sidney, Luca G. Guidotti, Max Shapiro, Robert Purcell, Francis V. Chisari

Research output: Contribution to journalArticle

Abstract

Using an in vitro peptide stimulation strategy, two chimpanzees that were acutely infected by the hepatitis B virus (HBV) produced peripheral blood CTL responses to several HBV-encoded epitopes that are known to be recognized by class I-restricted CTL in acutely infected humans. One animal responded to three HBV peptides that, in humans, are restricted by HLA-A2; the other animal responded to three peptides that are restricted by HLA-B35 and HLA-B51, members of the HLA-B7 supertype in man. The peptides recognized by each chimp corresponded with the ability of its class I molecules to bind peptides containing the HLA-A2 and HLA-B7 supermotifs. Similar, apparently class I-restricted CTL responses to some of these peptides were also detected in occasional HBV-uninfected chimps. These results demonstrate that the CTL repertoire overlaps in humans and chimps and that the HLA-A2 and HLA-B7 supertypes extend to the chimpanzee. Based on these results, the immunogenicity and efficacy of vaccines designed to induce CTL responses to human HLA-restricted viral epitopes may be testable in chimpanzees.

Original languageEnglish
Pages (from-to)4447-4455
Number of pages9
JournalJournal of Immunology
Volume161
Issue number8
Publication statusPublished - Oct 15 1998

ASJC Scopus subject areas

  • Immunology

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    Bertoni, R., Sette, A., Sidney, J., Guidotti, L. G., Shapiro, M., Purcell, R., & Chisari, F. V. (1998). Human class I supertypes and CTL repertoires extend to chimpanzees. Journal of Immunology, 161(8), 4447-4455.