Human cobalamin deficiency: Alterations in serum tumour necrosis factor-α and epidermal growth factor

M. Peracchi, F. Bamonti Catena, M. Pomati, M. De Franceschi, G. Scalabrino

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We have previously demonstrated that vitamin B12 (cobalamin)-deficient central neuropathy in the rat is associated with local overexpression of neurotoxic tumour necrosis factor (TNF)-α combined with locally decreased synthesis of neurotrophic epidermal growth factor (EGF). The aims of this study were to investigate whether a similar imbalance also occurs in the serum of adult patients with clinically confirmed cobalamin deficiency and whether it can be corrected by vitamin B12 replacement therapy. Patients and methods: We studied 34 adult patients with severe cobalamin deficiency, 12 patients with pure iron deficiency anaemia and 34 control subjects. Haematological markers of cobalamin deficiency and serum TNF-α and EGF levels were measured using commercial kits. Thirteen cobalamin-deficient patients were re-evaluated after 3 and 6 months of parenteral vitamin B12 treatment. Results: TNF-α was significantly higher (p

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalEuropean Journal of Haematology
Volume67
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Cobalamin
  • Cobalamin deficiency
  • Epidermal growth factor
  • Iron deficiency anaemia
  • Tumour necrosis factor-α

ASJC Scopus subject areas

  • Hematology

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