Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins

Monica Fedele, Antonella Bandiera, Gennaro Chiappetta, Sabrina Battista, Giuseppe Viglietto, Guidalberto Manfioletti, Amelia Casamassimi, Massimo Santoro, Vincenzo Giancotti, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

A correlation has previously been demonstrated between the presence of the three HMGI proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells; this being subsequently extended to experimental thyroid, lung, prostate, mammary, and skin carcinomas. Recently, we have demonstrated that expression of HMGI and HMGY proteins, coded for by the HMGI(Y) gene, is associated with the malignant phenotype of human thyroid neoplasias. Here, we show that HMGI(Y) gene expression is present both at the RNA and protein level in human colorectal carcinoma cell lines and tissues examined in this study. Conversely, no HMGI(Y) proteins were detected in normal intestinal mucosa. Therefore, these results suggest an involvement of HMGI and HMGY proteins overexpression in colorectal tumorigenesis.

Original languageEnglish
Pages (from-to)1896-1901
Number of pages6
JournalCancer Research
Volume56
Issue number8
Publication statusPublished - Apr 15 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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