Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system

L. Ciardelli; Francesca Garofoli; M. Stronati; I. Mazzucchelli; M. A. Avanzini; T. Figar; A. Gasparoni; A. De Silvestri; G. Sabatino; G. Chirico

Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system

L. Ciardelli, Francesca Garofoli, M. Stronati, I. Mazzucchelli, M. A. Avanzini, T. Figar, A. Gasparoni, A. De Silvestri, G. Sabatino, G. Chirico

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p

Original language	English
Pages (from-to)	781-786
Number of pages	6
Journal	International Journal of Immunopathology and Pharmacology
Volume	21
Issue number	4
Publication status	Published - Oct 2008

Keywords

Breastfeeding
Lymphocytes
Neonate

ASJC Scopus subject areas

Pharmacology
Immunology
Immunology and Allergy

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Ciardelli, L., Garofoli, F., Stronati, M., Mazzucchelli, I., Avanzini, M. A., Figar, T., Gasparoni, A., De Silvestri, A., Sabatino, G., & Chirico, G. (2008). Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system. International Journal of Immunopathology and Pharmacology, 21(4), 781-786.

Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system. / Ciardelli, L.; Garofoli, Francesca ; Stronati, M.; Mazzucchelli, I.; Avanzini, M. A.; Figar, T.; Gasparoni, A.; De Silvestri, A.; Sabatino, G.; Chirico, G.

In: International Journal of Immunopathology and Pharmacology, Vol. 21, No. 4, 10.2008, p. 781-786.

Research output: Contribution to journal › Article

Ciardelli, L. ; Garofoli, Francesca ; Stronati, M. ; Mazzucchelli, I. ; Avanzini, M. A. ; Figar, T. ; Gasparoni, A. ; De Silvestri, A. ; Sabatino, G. ; Chirico, G. / Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system. In: International Journal of Immunopathology and Pharmacology. 2008 ; Vol. 21, No. 4. pp. 781-786.

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