Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system

L. Ciardelli, Francesca Garofoli, M. Stronati, I. Mazzucchelli, M. A. Avanzini, T. Figar, A. Gasparoni, A. De Silvestri, G. Sabatino, G. Chirico

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p

Original languageEnglish
Pages (from-to)781-786
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume21
Issue number4
Publication statusPublished - Oct 2008

Fingerprint

Colostrum
Immune System
Lymphocytes
Cytokines
T-Lymphocytes
Fetal Blood
Helper-Inducer T-Lymphocytes
Phenotype
Cytotoxic T-Lymphocytes
Interleukin-4
Interleukin-10
Interleukin-2

Keywords

  • Breastfeeding
  • Lymphocytes
  • Neonate

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

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abstract = "Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn {"}virgin{"} immune system. CoTL showed memory phenotype while CBTL expressed mainly na{\"i}ve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p",
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T1 - Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system

AU - Ciardelli, L.

AU - Garofoli, Francesca

AU - Stronati, M.

AU - Mazzucchelli, I.

AU - Avanzini, M. A.

AU - Figar, T.

AU - Gasparoni, A.

AU - De Silvestri, A.

AU - Sabatino, G.

AU - Chirico, G.

PY - 2008/10

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N2 - Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p

AB - Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p

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