Abstract
Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p
| Original language | English |
|---|---|
| Pages (from-to) | 781-786 |
| Number of pages | 6 |
| Journal | International Journal of Immunopathology and Pharmacology |
| Volume | 21 |
| Issue number | 4 |
| Publication status | Published - Oct 2008 |
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Keywords
- Breastfeeding
- Lymphocytes
- Neonate
ASJC Scopus subject areas
- Pharmacology
- Immunology
- Immunology and Allergy
Cite this
Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system. / Ciardelli, L.; Garofoli, Francesca; Stronati, M.; Mazzucchelli, I.; Avanzini, M. A.; Figar, T.; Gasparoni, A.; De Silvestri, A.; Sabatino, G.; Chirico, G.
In: International Journal of Immunopathology and Pharmacology, Vol. 21, No. 4, 10.2008, p. 781-786.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Human colostrum lymphocytes aid their effector cytokines actively aid and the development of the newborn immune system
AU - Ciardelli, L.
AU - Garofoli, Francesca
AU - Stronati, M.
AU - Mazzucchelli, I.
AU - Avanzini, M. A.
AU - Figar, T.
AU - Gasparoni, A.
AU - De Silvestri, A.
AU - Sabatino, G.
AU - Chirico, G.
PY - 2008/10
Y1 - 2008/10
N2 - Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p
AB - Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn "virgin" immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p
KW - Breastfeeding
KW - Lymphocytes
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=59849101173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59849101173&partnerID=8YFLogxK
M3 - Article
C2 - 19144263
AN - SCOPUS:59849101173
VL - 21
SP - 781
EP - 786
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
SN - 0394-6320
IS - 4
ER -