TY - JOUR
T1 - Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors
AU - Mingari, Maria Cristina
AU - Pietra, Gabriella
AU - Moretta, Lorenzo
PY - 2005/6
Y1 - 2005/6
N2 - MHC class-1-specific inhibitory receptors were originally described in NK cells, in which they represent an important fail-safe mechanism that induces NK cell tolerance to normal self cells. These inhibitory NK receptors (iNKRs) were subsequently found expressed on different T cell subsets, primarily CD8 + cytolytic T lymphocytes (CTLs), in which they can inhibit T cell receptor mediated functions. Some iNKR+ CTLs are HLA-E-restricted, represent oligo- or monoclonal expansions, and can play a defensive role in viral infections. Although T cell activation, in the presence of certain cytokines, can induce the expression of the CD94-NKG2A heterodimeric receptor, the mechanism leading to the expression of killer immunoglobulin-like receptors (KIRs) is still unknown. The expression of iNKRs in T cells might contribute to the prevention of apoptotic cell death, thus allowing their survival and clonal expansion in vivo. In addition, iNKR+ T cells might contribute to peripheral self-tolerance.
AB - MHC class-1-specific inhibitory receptors were originally described in NK cells, in which they represent an important fail-safe mechanism that induces NK cell tolerance to normal self cells. These inhibitory NK receptors (iNKRs) were subsequently found expressed on different T cell subsets, primarily CD8 + cytolytic T lymphocytes (CTLs), in which they can inhibit T cell receptor mediated functions. Some iNKR+ CTLs are HLA-E-restricted, represent oligo- or monoclonal expansions, and can play a defensive role in viral infections. Although T cell activation, in the presence of certain cytokines, can induce the expression of the CD94-NKG2A heterodimeric receptor, the mechanism leading to the expression of killer immunoglobulin-like receptors (KIRs) is still unknown. The expression of iNKRs in T cells might contribute to the prevention of apoptotic cell death, thus allowing their survival and clonal expansion in vivo. In addition, iNKR+ T cells might contribute to peripheral self-tolerance.
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U2 - 10.1016/j.coi.2005.03.006
DO - 10.1016/j.coi.2005.03.006
M3 - Article
C2 - 15886123
AN - SCOPUS:18844363253
VL - 17
SP - 312
EP - 319
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 3
ER -