Human cytomegalovirus congenital (cCMV) infection following primary and nonprimary maternal infection: Perspectives of prevention through vaccine development

Research output: Contribution to journalReview article

Abstract

Congenital cytomegalovirus (cCMV) might occur as a result of the human cytomegalovirus (HCMV) primary (PI) or nonprimary infection (NPI) in pregnant women. Immune correlates of protection against cCMV have been partly identified only for PI. Following either PI or NPI, HCMV strains undergo latency. From a diagnostic standpoint, while the serological criteria for the diagnosis of PI are well-established, those for the diagnosis of NPI are still incomplete. Thus far, a recombinant gB subunit vaccine has provided the best results in terms of partial protection. This partial efficacy was hypothetically attributed to the post-fusion instead of the pre-fusion conformation of the gB present in the vaccine. Future efforts should be addressed to verify whether a new recombinant gB pre-fusion vaccine would provide better results in terms of prevention of both PI and NPI. It is still a matter of debate whether human hyperimmune globulin are able to protect from HCMV vertical transmission. In conclusion, the development of an HCMV vaccine that would prevent a significant portion of PI would be a major step forward in the development of a vaccine for both PI and NPI.

Original languageEnglish
Article number194
JournalVaccines
Volume8
Issue number2
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Bacterial artificial chromosome
  • Congenital cytomegalovirus
  • Cytotrophoblast
  • Dense bodies
  • GB
  • Hyperimmune globulin
  • Neutralizing antibodies
  • Non-primary infection
  • Pentameric complex
  • Primary infection

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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