Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus

Maria Grazia Revello, Milena Furione, Maurizio Zavattoni, Beatrice Tassis, Umberto Nicolini, Elisa Fabbri, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalJournal of Infectious Diseases
Volume197
Issue number4
DOIs
Publication statusPublished - Feb 15 2008

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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