Human cytomegalovirus in blood of immunocompetent persons during primary infection: Prognostic implications for pregnancy

Maria Grazia Revello, Maurizio Zavattoni, Antonella Sarasini, Elena Percivalle, Lavinia Simoncini, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review

Abstract

Human cytomegalovirus (HCMV) was investigated in peripheral blood leukocytes (PBL) of 52 immunocompetent patients (40 pregnant women) with primary HCMV infection by quantitative determination of pp65 antigenemia, viremia, and leukoDNAemia. pp65 antigenemia was detected in 12 (57.1%) of 21, 4 (25%) of 16, and 0 of 10 patients examined 1, 2, and 3 months after onset, respectively. Viremia was detected in 5 (26.3%) of 19 patients during the first month only. LeukoDNAemia was detected in 20 of 20, 17 (89.5%) of 19, and 9 (47.3%) of 19 patients tested 1, 2, and 3 months after onset, respectively. Four (26.6%) of 15 patients were still DNAemia-positive at 4-6 months, whereas none were positive at >6 months. HCMV was not detected in PBL of 20 HCMV-immune donors or of 9 seropositive subjects with recurrent infection. Virus levels were low by all assays and did not correlate with clinical course of infection, intrauterine transmission, or severity of outcome. Invasive procedures in the presence of maternal leukoDNAemia did not seem to interfere with vertical transmission of HCMV infection.

Original languageEnglish
Pages (from-to)1170-1175
Number of pages6
JournalJournal of Infectious Diseases
Volume177
Issue number5
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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