Human cytomegalovirus nuclear and cytoplasmic dense bodies

B. Severi, M. P. Landini, G. Cenacchi, N. Zini, N. M. Maraldi

Research output: Contribution to journalArticlepeer-review


One of the characteristic features of cytomegalovirus (CMV) replication is the formation of cytoplasmic dense bodies. Recent findings revealed similar structures also in the nuclei of CMV-infected cells. By transmission electron microscopy, immuno electronmicroscopy, and cytochemistry, we have studied the morphogenetic steps and macromolecular composition of both structures. Our results show that both structures contain DNA, RNA and viral antigenic proteins. Nuclear dense bodies are probably an expression of a stimulated cellular metabolism, while cytoplasmic dense bodies may represent the site where surplus cellular and viral molecules are stored before being eliminated.

Original languageEnglish
Pages (from-to)193-207
Number of pages15
JournalArchives of Virology
Issue number1-2
Publication statusPublished - Mar 1992

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics


Dive into the research topics of 'Human cytomegalovirus nuclear and cytoplasmic dense bodies'. Together they form a unique fingerprint.

Cite this