Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates

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Abstract

Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.

Original languageEnglish
Pages (from-to)1225-1233
Number of pages9
JournalArchives of Virology
Volume151
Issue number6
DOIs
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

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