TY - JOUR
T1 - Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates
AU - Baldanti, F.
AU - Paolucci, S.
AU - Campanini, G.
AU - Sarasini, A.
AU - Percivalle, E.
AU - Revello, M. G.
AU - Gerna, G.
PY - 2006/6
Y1 - 2006/6
N2 - Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.
AB - Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.
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U2 - 10.1007/s00705-005-0696-5
DO - 10.1007/s00705-005-0696-5
M3 - Article
C2 - 16380811
AN - SCOPUS:33744502353
VL - 151
SP - 1225
EP - 1233
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 6
ER -