Human diabetic cataract: Role of lipid peroxidation

E. Altomare, G. Vendemiale, I. Grattagliano, P. Angelini, T. Micelli-Ferrari, L. Cardia

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

To test whether impaired glutathione redox status may be related to lens oxidative damage in humans, we measured glutathione (total and oxidised forms) and malondialdehyde, a lipid peroxidation product, in clear lenses and diabetic and non-diabetic cataracts. Diabetic cataracts were divided into 2 subgroups with either intact or abnormal haemo-ocular barrier as evaluated by preoperative iridography. Decreased total glutathione values were observed in cataractous (diabetic and non-diabetic) as compared to clear lenses (p <0.001), whereas enhanced oxidised glutathione levels were found in diabetic caracts as compared to non-diabetic ones and clear lenses (p <0.001). Malondialdehyde concentrations were significantly higher in all types of cataracts, especially myopic and diabetic ones, than in clear lenses (p <0.001). Moreover, malondialdehyde levels in diabetic lenses were inversely correlated with total glutathione (r = -0.80; p <0.001) and linearly correlated with oxidised glutathione values (r = 0.76; p <0.001). Finally, glutathione redox status was found to be more seriously impaired in lenses from diabetic patients with abnormal than intact haemo-ocular barrier. These data suggest a contributory role of lipid peroxidation and glutathione oxidation and consumption in the pathogenesis of cataract, especially in diabetic lenses with haemo-ocular barrier abnormality.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalDiabete et Metabolisme
Volume21
Issue number3
Publication statusPublished - 1995

Fingerprint

Cataract
Lipid Peroxidation
Lenses
Glutathione
Glutathione Disulfide
Malondialdehyde
Oxidation-Reduction
Eye Abnormalities

Keywords

  • diabetic cataract
  • glutathione (GSH)
  • iridography
  • lipid peroxidation
  • malondialdehyde (MDA)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Altomare, E., Vendemiale, G., Grattagliano, I., Angelini, P., Micelli-Ferrari, T., & Cardia, L. (1995). Human diabetic cataract: Role of lipid peroxidation. Diabete et Metabolisme, 21(3), 173-179.

Human diabetic cataract : Role of lipid peroxidation. / Altomare, E.; Vendemiale, G.; Grattagliano, I.; Angelini, P.; Micelli-Ferrari, T.; Cardia, L.

In: Diabete et Metabolisme, Vol. 21, No. 3, 1995, p. 173-179.

Research output: Contribution to journalArticle

Altomare, E, Vendemiale, G, Grattagliano, I, Angelini, P, Micelli-Ferrari, T & Cardia, L 1995, 'Human diabetic cataract: Role of lipid peroxidation', Diabete et Metabolisme, vol. 21, no. 3, pp. 173-179.
Altomare E, Vendemiale G, Grattagliano I, Angelini P, Micelli-Ferrari T, Cardia L. Human diabetic cataract: Role of lipid peroxidation. Diabete et Metabolisme. 1995;21(3):173-179.
Altomare, E. ; Vendemiale, G. ; Grattagliano, I. ; Angelini, P. ; Micelli-Ferrari, T. ; Cardia, L. / Human diabetic cataract : Role of lipid peroxidation. In: Diabete et Metabolisme. 1995 ; Vol. 21, No. 3. pp. 173-179.
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