Human diabetic cataract: Role of lipid peroxidation

E. Altomare, G. Vendemiale, I. Grattagliano, P. Angelini, T. Micelli-Ferrari, L. Cardia

Research output: Contribution to journalArticle

Abstract

To test whether impaired glutathione redox status may be related to lens oxidative damage in humans, we measured glutathione (total and oxidised forms) and malondialdehyde, a lipid peroxidation product, in clear lenses and diabetic and non-diabetic cataracts. Diabetic cataracts were divided into 2 subgroups with either intact or abnormal haemo-ocular barrier as evaluated by preoperative iridography. Decreased total glutathione values were observed in cataractous (diabetic and non-diabetic) as compared to clear lenses (p <0.001), whereas enhanced oxidised glutathione levels were found in diabetic caracts as compared to non-diabetic ones and clear lenses (p <0.001). Malondialdehyde concentrations were significantly higher in all types of cataracts, especially myopic and diabetic ones, than in clear lenses (p <0.001). Moreover, malondialdehyde levels in diabetic lenses were inversely correlated with total glutathione (r = -0.80; p <0.001) and linearly correlated with oxidised glutathione values (r = 0.76; p <0.001). Finally, glutathione redox status was found to be more seriously impaired in lenses from diabetic patients with abnormal than intact haemo-ocular barrier. These data suggest a contributory role of lipid peroxidation and glutathione oxidation and consumption in the pathogenesis of cataract, especially in diabetic lenses with haemo-ocular barrier abnormality.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalDiabete et Metabolisme
Volume21
Issue number3
Publication statusPublished - 1995

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Keywords

  • diabetic cataract
  • glutathione (GSH)
  • iridography
  • lipid peroxidation
  • malondialdehyde (MDA)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Altomare, E., Vendemiale, G., Grattagliano, I., Angelini, P., Micelli-Ferrari, T., & Cardia, L. (1995). Human diabetic cataract: Role of lipid peroxidation. Diabete et Metabolisme, 21(3), 173-179.