TY - JOUR
T1 - Human Elongation Factor EF-1β
T2 - Cloning and Characterization of the EF1β5a Gene and Assignment of EF-1β Isoforms to Chromosomes 2, 5, 15, and X
AU - Pizzuti, A.
AU - Gennarelli, M.
AU - Novelli, G.
AU - Colosimo, A.
AU - Locicero, S.
AU - Caskey, C. T.
AU - Dallapiccola, B.
PY - 1993/11/30
Y1 - 1993/11/30
N2 - We report here the isolation and characterization of a novel human elongation factor-1 β (EF-1β) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1β cDNAs. We also assigned the loci for three other EF-1β isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1β loci demontrates the genetic heterogeneity of human EF-1β peptides.
AB - We report here the isolation and characterization of a novel human elongation factor-1 β (EF-1β) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1β cDNAs. We also assigned the loci for three other EF-1β isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1β loci demontrates the genetic heterogeneity of human EF-1β peptides.
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U2 - 10.1006/bbrc.1993.2454
DO - 10.1006/bbrc.1993.2454
M3 - Article
C2 - 8250921
AN - SCOPUS:0027427141
VL - 197
SP - 154
EP - 162
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -