Human Elongation Factor EF-1β: Cloning and Characterization of the EF1β5a Gene and Assignment of EF-1β Isoforms to Chromosomes 2, 5, 15, and X

A. Pizzuti, M. Gennarelli, G. Novelli, A. Colosimo, S. Locicero, C. T. Caskey, B. Dallapiccola

Research output: Contribution to journalArticlepeer-review

Abstract

We report here the isolation and characterization of a novel human elongation factor-1 β (EF-1β) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1β cDNAs. We also assigned the loci for three other EF-1β isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1β loci demontrates the genetic heterogeneity of human EF-1β peptides.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume197
Issue number1
DOIs
Publication statusPublished - Nov 30 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

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