Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Hervé Perron; Raphaëlle Germi; Corinne Bernard; Marta Garcia-Montojo; Cécile Deluen; Laurent Farinelli; Raphaël Faucard; Francisco Veas; Ilias Stefas; Babs O. Fabriek; Jack Van-Horssen; Paul Van-Der-Valk; Claire Gerdil; Roberta Mancuso; Marina Saresella; Mario Clerici; Sébastien Marcel; Alain Creange; Rosella Cavaretta; Domenico Caputo; Giannina Arru; Patrice Morand; Alois B. Lang; Stefano Sotgiu; Klemens Ruprecht; Peter Rieckmann; Pablo Villoslada; Michel Chofflon; Jose Boucraut; Jean Pelletier; Hans Peter Hartung

doi:10.1177/1352458512441381

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Hervé Perron, Raphaëlle Germi, Corinne Bernard, Marta Garcia-Montojo, Cécile Deluen, Laurent Farinelli, Raphaël Faucard, Francisco Veas, Ilias Stefas, Babs O. Fabriek, Jack Van-Horssen, Paul Van-Der-Valk, Claire Gerdil, Roberta Mancuso, Marina Saresella, Mario Clerici, Sébastien Marcel, Alain Creange, Rosella Cavaretta, Domenico CaputoGiannina Arru, Patrice Morand, Alois B. Lang, Stefano Sotgiu, Klemens Ruprecht, Peter Rieckmann, Pablo Villoslada, Michel Chofflon, Jose Boucraut, Jean Pelletier, Hans Peter Hartung

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family W (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals.

Original language	English
Pages (from-to)	1721-1736
Number of pages	16
Journal	Multiple Sclerosis Journal
Volume	18
Issue number	12
DOIs	https://doi.org/10.1177/1352458512441381
Publication status	Published - 2012

Keywords

biomarker
endogenous retrovirus
HERV-W
MSRV
multiple sclerosis
syncytin
TLR4

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Perron, H., Germi, R., Bernard, C., Garcia-Montojo, M., Deluen, C., Farinelli, L., Faucard, R., Veas, F., Stefas, I., Fabriek, B. O., Van-Horssen, J., Van-Der-Valk, P., Gerdil, C., Mancuso, R., Saresella, M., Clerici, M., Marcel, S., Creange, A., Cavaretta, R., ... Hartung, H. P. (2012). Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Multiple Sclerosis Journal, 18(12), 1721-1736. https://doi.org/10.1177/1352458512441381

Perron, H, Germi, R, Bernard, C, Garcia-Montojo, M, Deluen, C, Farinelli, L, Faucard, R, Veas, F, Stefas, I, Fabriek, BO, Van-Horssen, J, Van-Der-Valk, P, Gerdil, C, Mancuso, R , Saresella, M , Clerici, M, Marcel, S, Creange, A, Cavaretta, R, Caputo, D, Arru, G, Morand, P, Lang, AB, Sotgiu, S, Ruprecht, K, Rieckmann, P, Villoslada, P, Chofflon, M, Boucraut, J, Pelletier, J & Hartung, HP 2012, 'Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease', Multiple Sclerosis Journal, vol. 18, no. 12, pp. 1721-1736. https://doi.org/10.1177/1352458512441381

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title = "Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease",

abstract = "Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family W (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals.",

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T1 - Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

AU - Perron, Hervé

AU - Germi, Raphaëlle

AU - Bernard, Corinne

AU - Garcia-Montojo, Marta

AU - Deluen, Cécile

AU - Farinelli, Laurent

AU - Faucard, Raphaël

AU - Veas, Francisco

AU - Stefas, Ilias

AU - Fabriek, Babs O.

AU - Van-Horssen, Jack

AU - Van-Der-Valk, Paul

AU - Gerdil, Claire

AU - Mancuso, Roberta

AU - Saresella, Marina

AU - Clerici, Mario

AU - Marcel, Sébastien

AU - Creange, Alain

AU - Cavaretta, Rosella

AU - Caputo, Domenico

AU - Arru, Giannina

AU - Morand, Patrice

AU - Lang, Alois B.

AU - Sotgiu, Stefano

AU - Ruprecht, Klemens

AU - Rieckmann, Peter

AU - Villoslada, Pablo

AU - Chofflon, Michel

AU - Boucraut, Jose

AU - Pelletier, Jean

AU - Hartung, Hans Peter

PY - 2012

Y1 - 2012

N2 - Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family W (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals.

AB - Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family W (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals.

KW - biomarker

KW - endogenous retrovirus

KW - HERV-W

KW - MSRV

KW - multiple sclerosis

KW - syncytin

KW - TLR4

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JF - Multiple Sclerosis

SN - 1352-4585

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Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Abstract

Keywords

ASJC Scopus subject areas

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