Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Hervé Perron, Raphaëlle Germi, Corinne Bernard, Marta Garcia-Montojo, Cécile Deluen, Laurent Farinelli, Raphaël Faucard, Francisco Veas, Ilias Stefas, Babs O. Fabriek, Jack Van-Horssen, Paul Van-Der-Valk, Claire Gerdil, Roberta Mancuso, Marina Saresella, Mario Clerici, Sébastien Marcel, Alain Creange, Rosella Cavaretta, Domenico CaputoGiannina Arru, Patrice Morand, Alois B. Lang, Stefano Sotgiu, Klemens Ruprecht, Peter Rieckmann, Pablo Villoslada, Michel Chofflon, Jose Boucraut, Jean Pelletier, Hans Peter Hartung

Research output: Contribution to journalArticle

Abstract

Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family W (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals.

Original languageEnglish
Pages (from-to)1721-1736
Number of pages16
JournalMultiple Sclerosis Journal
Volume18
Issue number12
DOIs
Publication statusPublished - 2012

Keywords

  • biomarker
  • endogenous retrovirus
  • HERV-W
  • MSRV
  • multiple sclerosis
  • syncytin
  • TLR4

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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  • Cite this

    Perron, H., Germi, R., Bernard, C., Garcia-Montojo, M., Deluen, C., Farinelli, L., Faucard, R., Veas, F., Stefas, I., Fabriek, B. O., Van-Horssen, J., Van-Der-Valk, P., Gerdil, C., Mancuso, R., Saresella, M., Clerici, M., Marcel, S., Creange, A., Cavaretta, R., ... Hartung, H. P. (2012). Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Multiple Sclerosis Journal, 18(12), 1721-1736. https://doi.org/10.1177/1352458512441381