Human eosinophils and parasitic diseases. II. Characterization of two cell fractions isolated at different densities

C. De Simone, G. Donneli, D. Meli, F. Rosati, F. Sorice

Research output: Contribution to journalArticlepeer-review

Abstract

A new procedure, based on centrifugation through mutliple discontinuous gradients of polyvinylpyrrolidone coated silica particles has been developed for the separation of almost pure eosinophils from blood samples of healthy donors. When this technique is employed for the purification of eosinophils from the peripheral blood of patients with parasitic diseases, two cell fractions almost pure in eosinophil granulocytes are harvested at different densities. Preliminary results, concerning the characterization of these cell fractions, indicate that in the terms of detectable membrane receptors and K cell activity, two distinct eosinophil subpopulation can be recognized.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalClinical and Experimental Immunology
Volume48
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology

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