Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules

Vincenzo Marotta, Giacomo Russo, Claudio Gambardella, Marica Grasso, Domenico La Sala, Maria Grazia Chiofalo, Raffaella D'Anna, Alessandro Puzziello, Giovanni Docimo, Stefania Masone, Francesco Barbato, Annamaria Colao, Antongiulio Faggiano, Lucia Grumetto

Research output: Contribution to journalArticle

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Abstract

Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environmental pollution, most of which exerting endocrine-disrupting activity, in thyroid cancer development. The increasing incidence of differentiated thyroid cancer (DTC) may be related to the rising production and environmental dissemination of pollutants. Fifty-five patients, twenty-seven with diagnosis of benign thyroid nodules and twenty-eight suffering from differentiated thyroid cancer, were enrolled and the concentration levels of seven bisphenols, two phthalates (i.e. di(2-ethylhexyl) phthalate (DEHP) and its main metabolite, mono-(2-ethyl-hexyl) phthalate) (MEHP)), two chlorobenzenes, (1,4-dichlorobenzene and 1,2,4,5-tetrachlorobenzene), and 3 phenol derivatives (2-chlorophenol, 4- nonylphenol, and triclosan) were determined in their serum by using a validated analytical method based on high performance liquid chromatography with ultraviolet tandem fluorescence detection. A significant relationship was found between malignancy and the detection in the serum of both bisphenol AF and DEHP. Indeed, their presence confers a more than fourteen times higher risk of developing differentiated thyroid cancer. Relationship between these two pollutants and the risk of malignancy was dose-independent and not mediated by higher thyroid stimulating hormone levels. Even if a conclusive evidence cannot still be drawn and larger prospective studies are needed, the exposure to low doses of environmental endocrine-disrupting contaminants can be considered consistent with the development of thyroid cancer.

Original languageEnglish
Pages (from-to)885-894
Number of pages10
JournalChemosphere
Volume218
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Thyroid Nodule
Thyroid Neoplasms
phthalate
cancer
Organic pollutants
High performance liquid chromatography
Metabolites
pollutant
Phenols
Toxicity
Chlorobenzenes
Pollution
Fluorescence
Health
Triclosan
Impurities
serum
Derivatives
Environmental Pollutants
Thyrotropin

Keywords

  • Endocrine disrupting chemicals
  • Environment
  • Pollutants
  • Risk assessment
  • Thyroid cancer

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. / Marotta, Vincenzo; Russo, Giacomo; Gambardella, Claudio; Grasso, Marica; La Sala, Domenico; Chiofalo, Maria Grazia; D'Anna, Raffaella; Puzziello, Alessandro; Docimo, Giovanni; Masone, Stefania; Barbato, Francesco; Colao, Annamaria; Faggiano, Antongiulio; Grumetto, Lucia.

In: Chemosphere, Vol. 218, 01.03.2019, p. 885-894.

Research output: Contribution to journalArticle

Marotta, V, Russo, G, Gambardella, C, Grasso, M, La Sala, D, Chiofalo, MG, D'Anna, R, Puzziello, A, Docimo, G, Masone, S, Barbato, F, Colao, A, Faggiano, A & Grumetto, L 2019, 'Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules', Chemosphere, vol. 218, pp. 885-894. https://doi.org/10.1016/j.chemosphere.2018.11.084
Marotta, Vincenzo ; Russo, Giacomo ; Gambardella, Claudio ; Grasso, Marica ; La Sala, Domenico ; Chiofalo, Maria Grazia ; D'Anna, Raffaella ; Puzziello, Alessandro ; Docimo, Giovanni ; Masone, Stefania ; Barbato, Francesco ; Colao, Annamaria ; Faggiano, Antongiulio ; Grumetto, Lucia. / Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. In: Chemosphere. 2019 ; Vol. 218. pp. 885-894.
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AU - La Sala, Domenico

AU - Chiofalo, Maria Grazia

AU - D'Anna, Raffaella

AU - Puzziello, Alessandro

AU - Docimo, Giovanni

AU - Masone, Stefania

AU - Barbato, Francesco

AU - Colao, Annamaria

AU - Faggiano, Antongiulio

AU - Grumetto, Lucia

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