Human foetal prolactin but not thyrotropin secretion is decreased by bromocriptine

E. Roti, G. Robuschi, A. Alboni, L. d'Amato, M. Montermini, E. Gardini, M. Salvi, E. Borciani, E. Dall'Aglio, S. Bisi

Research output: Contribution to journalArticlepeer-review

Abstract

In the adult, dopamine inhibits prolactin (Prl) secretion and less so thyrotropin (TSH) release. Little information is available concerning the role of dopaminergic stimuli in the regulation of TSH and Prl secretion in the term human foetus. The dopamine agonist, bromocriptine (5 mg), or placebo were randomly administered orally to 120 pregnant women during labour. Maternal and foetal cord blood was obtained at parturition and analyzed for Prl, TSH, T4, T3 and rT3 concentrations. Since the time of parturition is unpredictable, maternal and cord blood hormone values were grouped at intervals of time from the time of bromocriptine or placebo administration to delivery. Hormone values were compared between the bromocriptine and placebo groups by two-way analysis of variance (ANOVA). Bromocriptine markedly inhibited maternal serum Prl concentrations compared to values in the placebo treated women (P

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalActa Endocrinologica
Volume112
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Endocrinology

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