Human granulocyte colony-stimulating factor (rHuG-CSF) for treatment of neutropenia in Shwachman syndrome

A. Ventura, D. Dragovich, P. Luxardo, G. Zanazzo

Research output: Contribution to journalArticlepeer-review

Abstract

We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating factor (rHuG-CSF). Daily injections of 7.5 μg/kg/day significantly increased the absolute neutrophil count and he was free from infections. In order to avoid the risk of side effects and to improve the child's quality of life, we intermittently administered lower doses of rHuG-CSF. A weekly dose of 2 μg/kg/day was able to maintain the absolute neutrophil count high enough (0.58-1.2 x 109/L) to prevent suppurative infections. During the follow-up period (2.5 years) we tried suspending rHuG-CSF twice, but the absolute neutrophil count (0.18-0.31 x 109/L) fell significantly and suppurative infections reoccurred (otitis, perianal abscess). rHuG-CSF may be a useful therapeutic agent in patients with symptomatic neutropenia in SS.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalHaematologica
Volume80
Issue number3
Publication statusPublished - 1995

Keywords

  • granulocyte colony-stimulating factor (rHuG-CSF)
  • neutropenia
  • pancreatic failure
  • Shwachman syndrome

ASJC Scopus subject areas

  • Hematology

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