Human granulocyte-macrophage colony-stimulating factor is a growth factor active on human ovarian cancer cells

Guido Cimoli, Patrizia Russo, Giovanna Billi, Gabriella Lucia Mariani, Elisabetta Rovini, Marco Venturini

Research output: Contribution to journalArticle

Abstract

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a regulatory glycoprotein that stimulates the production of granulocytes and macrophages from committed hematopoietic progenitor cells both in vitro and in vivo. In this report, we show that recombinant human GM-CSF enhances colony formation by nonhematopoietic human ovarian cancer cell lines, IGROV-1, A2774, ME-180, Pa-1 and A2780. GM-CSF also enhanced the colony formation by cells obtained from fresh ascites of a patient with ovarian mucinous cystadenocarcinoma and a patient with serous papillary ovarian carcinoma. Our observations were made with GM-CSF concentrations between 0.1 to 1 ng/ml; these concentrations are equivalent to the dosages generally used for bone marrow recovery after chemotherapy.

Original languageEnglish
Pages (from-to)1196-1198
Number of pages3
JournalJapanese Journal of Cancer Research
Volume82
Issue number11
Publication statusPublished - Nov 1991

Keywords

  • Clonal growth
  • GM-CSF
  • Ovarian cancer cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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