Human handedness and asymmetry of the motor cortical silent period

Alberto Priori, Antonio Oliviero, Edoardo Donati, Leonardo Callea, Laura Bertolasi, John C. Rothwell

Research output: Contribution to journalArticlepeer-review

Abstract

We performed transcranial magnetic stimulation of the motor cortex in 22 left-handed and 25 right-handed subjects during active contraction of a small hand muscle. Motor evoked potentials had the same latency, amplitude and threshold on both sides of the body, whilst the silent period duration was shorter in the dominant hand. Silent periods elicited by nerve and brainstem stimulation were the same in both hands. Since the latter part of the cortical silent period is due mainly to withdrawal of corticospinal input to spinal motoneurones, we speculate that the results are compatible with the suggestion that tonic contractions of the non-dominant hand are associated with a greater involvement of the corticospinal tract than those of the dominant hand. It also seems likely that there is an asymmetry in the excitability of cortical inhibitory mechanisms with those responsible for the cortical silent period being less excitable in the dominant motor cortex.

Original languageEnglish
Pages (from-to)390-396
Number of pages7
JournalExperimental Brain Research
Volume128
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Handedness
  • Magnetic stimulation
  • Silent period

ASJC Scopus subject areas

  • Neuroscience(all)

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